NPR3 Antibody – Rabbit Polyclonal

ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: integral to plasma membrane

Molecular Function: protein homodimerization activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled

Biological Process: regulation of osteoblast proliferation; phosphoinositide-mediated signaling; negative regulation of smooth muscle cell proliferation; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; negative regulation of adenylate cyclase activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase inhibiting pathway; pancreatic juice secretion; skeletal development