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OGDH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8548366

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OGDH, Polyclonal Antibody
Full Product Name
OGDH Rabbit pAb
Product Gene Name
anti-OGDH antibody
Product Synonym Names
E1k; OGDC; AKGDH
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purity/Purification
Affinity Purified
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
116kDa
OMIM
613022
3D Structure
ModBase 3D Structure for Q02218
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human OGDH (NP_001003941.1).
Cellular Localization
Mitochondrion
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-OGDH antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-OGDH antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200

Other Notes

Small volumes of anti-OGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OGDH purchase

MBS8548366 is an antibody targeting OGDH. Also known as OGDH Rabbit pAb. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OGDH. It may not necessarily be applicable to this product.

NCBI GI #
160332299
NCBI GeneID
4967
NCBI Accession #
Q02218.3
UniProt Primary Accession #
Q02218
UniProt Related Accession #
Q02218
NCBI Official Full Name
2-oxoglutarate dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
oxoglutarate dehydrogenase
NCBI Official Symbol
OGDH
NCBI Official Synonym Symbols
E1k; OGDC; AKGDH
UniProt Protein Name
2-oxoglutarate dehydrogenase, mitochondrial
UniProt Synonym Protein Names
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
UniProt Gene Name
OGDH
UniProt Synonym Gene Names
OGDC-E1
UniProt Entry Name
ODO1_HUMAN
NCBI Protein Information
2-oxoglutarate dehydrogenase, mitochondrial

NCBI Summary for OGDH

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
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UniProt Comments for OGDH

OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - lysine degradation; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; EC 1.2.4.2

Chromosomal Location of Human Ortholog: 7p14-p13

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; cytosol; oxoglutarate dehydrogenase complex

Molecular Function: chaperone binding; metal ion binding; heat shock protein binding; thiamin pyrophosphate binding; oxoglutarate dehydrogenase (succinyl-transferring) activity

Biological Process: generation of precursor metabolites and energy; glycolysis; striatum development; succinyl-CoA metabolic process; tricarboxylic acid cycle; hippocampus development; pyramidal neuron development; thalamus development; 2-oxoglutarate metabolic process; cellular metabolic process; cerebellar cortex development; tangential migration from the subventricular zone to the olfactory bulb; NADH metabolic process; lysine catabolic process

Disease: Alpha-ketoglutarate Dehydrogenase Deficiency
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Research Articles on OGDH

1. The data indicate that amino acid/nucleotide metabolism-related genes OGDH, PPAT and PCCA acquire somatic mutations in microsatellite instability-high gastric cancers and colorectal cancers and that mutational intratumoral heterogeneity may occur in at least some of these tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OGDH antibody

 Reference Product  PubMed Publications
 IDH3G antibody  >1 publications with OGDH and IDH3G
 IDH3A antibody  >1 publications with OGDH and IDH3A
 DLST antibody  >1 publications with OGDH and DLST

Pathways associated with anti-OGDH antibody

 Products by Pathway  Pathway Diagram
 2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway antibodies  2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway Diagram
 2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway antibodies  2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram

Diseases associated with anti-OGDH antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >3 publications with OGDH and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with OGDH and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with OGDH and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with OGDH and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with OGDH and Liver Diseases
 Liver Cirrhosis Antibodies  >1 publications with OGDH and Liver Cirrhosis
 Fatty Liver Antibodies  >1 publications with OGDH and Fatty Liver

Organs/Tissues associated with anti-OGDH antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >15 publications with OGDH and Muscle
 Heart Antibodies  >8 publications with OGDH and Heart
 Liver Antibodies  >8 publications with OGDH and Liver
 Brain Antibodies  >6 publications with OGDH and Brain
 Blood Antibodies  >5 publications with OGDH and Blood
 Kidney Antibodies  >3 publications with OGDH and Kidney
 Pancreas Antibodies  >3 publications with OGDH and Pancreas
 Adipose Tissue Antibodies  >3 publications with OGDH and Adipose Tissue
 Vascular Antibodies  >3 publications with OGDH and Vascular
 Connective Tissue Antibodies  >2 publications with OGDH and Connective Tissue
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