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OSR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9610530

MBS9610530 is an antibody targeting OSR1. Also known as Phospho-OSR1 (Ser339) Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$310 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OSR1, Polyclonal Antibody
Full Product Name
Phospho-OSR1 (Ser339) Antibody
Product Gene Name
anti-OSR1 antibody
Product Synonym Names
2210022N24Rik; 2810422B09Rik; AI462649; AW209236; KIAA1101; mKIAA1101; OSR 1; OSR1; OTTHUMP00000209062; Oxidative stress responsive 1; Oxidative stress responsive 1 protein; Oxidative stress-responsive 1 protein; OXSR 1; OXSR1; OXSR1_HUMAN; Serine/threonine protein kinase OSR1; Serine/threonine-protein kinase OSR1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Concentration
~1mg/ml (lot specific)
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
OSR1 (Ser339) peptide (MBS9618248) is used for blocking the activity of OSR1 (Ser339) antibody (MBS9610530)
Molecular Weight
58 kDa
OMIM
604046
3D Structure
ModBase 3D Structure for O95747
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human OSR1 around the phosphorylation site of Ser339.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-OSR1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-OSR1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-OSR1 antibody

MBS9610530 at 1/100 staining mouse spleen tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the Ab for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit Ab was used as the secondary Ab.
Rabbit Anti-OSR1 Polyclonal Antibody – Cat# MBS9610530

Western Blot (WB) of anti-OSR1 antibody

Western blot analysis of extracts from various samples, using Phospho-OSR1 (Ser339) Ab.
Lane 1: Mouse brain, blocked with antigen-specific peptides.
Lane 2: Mouse brain.
Lane 3: Raw264.7 cells(serum starvation treatment).
Rabbit Anti-OSR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9610530

Other Notes

Small volumes of anti-OSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OSR1. It may not necessarily be applicable to this product.

NCBI GI #
4826878
NCBI GeneID
9943
NCBI Accession #
NP_005100.1
UniProt Primary Accession #
O95747
UniProt Related Accession #
O95747
GenBank Nucleotide #
NP_005100.1
NCBI Official Full Name
serine/threonine-protein kinase OSR1
NCBI Official Synonym Full Names
oxidative stress responsive kinase 1
NCBI Official Symbol
OXSR1
NCBI Official Synonym Symbols
OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
Protein Family
Protein odd-skipped
UniProt Gene Name
OXSR1
UniProt Synonym Gene Names
KIAA1101; OSR1
UniProt Entry Name
OXSR1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase OSR1

NCBI Summary for OSR1

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

UniProt Comments for OSR1

OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; Kinase, protein; STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
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Research Articles on OSR1

1. Increased expression of proteins STAT5B, GRB2, and OXSR1 was related to a higher probability of metastasis. Multivariate analysis demonstrated that tumor grade and STAT5B were independent prognostic factors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OSR1 antibody

 Reference Product  PubMed Publications
 PAK1 antibody  >1 publications with OSR1 and PAK1

Diseases associated with anti-OSR1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >6 publications with OSR1 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with OSR1 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with OSR1 and Necrosis
 Hyperkalemia Antibodies  >1 publications with OSR1 and Hyperkalemia
 Kidney Diseases Antibodies  >1 publications with OSR1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with OSR1 and Fibrosis
 Myocardial Infarction Antibodies  >1 publications with OSR1 and Myocardial Infarction
 Neoplasms Antibodies  >1 publications with OSR1 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with OSR1 and Lung Neoplasms

Organs/Tissues associated with anti-OSR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with OSR1 and Brain
 Blood Antibodies  >3 publications with OSR1 and Blood
 Prostate Antibodies  >2 publications with OSR1 and Prostate
 Nerve Antibodies  >2 publications with OSR1 and Nerve
 Muscle Antibodies  >1 publications with OSR1 and Muscle
 Kidney Antibodies  >1 publications with OSR1 and Kidney
 Intestine Antibodies  >1 publications with OSR1 and Intestine
 Pancreas Antibodies  >1 publications with OSR1 and Pancreas
 Skin Antibodies  >1 publications with OSR1 and Skin
 Lung Antibodies  >1 publications with OSR1 and Lung
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