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p18 INK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9410290

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.Youzhong Yuan, Cancer Res., Jan 2006; 66: 343 - 351. A. Koenig, Vet. Pathol., Jul 2002; 39: 458.… More details

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Product Overview

Online Datasheet in PDF
Product Name
p18 INK, Polyclonal Antibody
Full Product Name
p18 INK Antibody
Product Gene Name
Product Synonym Names
OTTHUMP00000046546; p18(INK4C); p18-INK4C; CDK6 inhibitor p18; cyclin-dependent inhibitor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total p18 INK protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
18,127 Da
OMIM
603369
3D Structure
ModBase 3D Structure for P42773
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from human p18 INK antibody.
Target Name
p18 INK

Product Categories/Family for anti-p18 INK antibody

Applications Tested/Suitable for anti-p18 INK antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-p18 INK antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Western Blot (WB) of anti-p18 INK antibody

Western blot analysis of extracts from COS7 cells, using p18 INK antibody.
Rabbit Anti-p18 INK Polyclonal Antibody – Cat# MBS9410290

Immunohistochemistry (IHC) of anti-p18 INK antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p18 INK antibody.
Rabbit Anti-p18 INK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9410290

Other Notes

Small volumes of anti-p18 INK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for p18 INK purchase

MBS9410290 is an antibody targeting p18 INK. Also known as p18 INK Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for p18 INK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor C
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NCBI Official Symbol
CDKN2C
NCBI Official Synonym Symbols
p18; INK4C; p18-INK4C
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor C
UniProt Synonym Protein Names
Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
UniProt Gene Name
CDKN2C
UniProt Synonym Gene Names
CDKN6
UniProt Entry Name
CDN2C_HUMAN
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor C

NCBI Summary for p18 INK

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for p18 INK

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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