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P2X2 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178008

Description: Rabbit IgG polyclonal antibody for P2X purinoceptor 2(P2RX2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.Background: The P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by… More details

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Product Overview

Online Datasheet in PDF
Product Name
P2X2, Polyclonal Antibody
Full Product Name
Anti-P2X2 Antibody
Product Gene Name
anti-P2X2 antibody
Product Synonym Names
P2X purinoceptor 2; ATP receptor; MGC129601; P2RX 2; P2RX2; P2RX2_HUMAN; P2X purinoceptor 2; P2X Receptor subunit 2; P2X2; P2X2a; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 2; Purinergic receptor P2X2 isoform A; Purinergic receptor P2X2 isoform B; Purinergic receptor P2X2 isoform C; Purinergic receptor P2X2 isoform D; Purinergic receptor P2X2 isoform H; Purinergic receptor P2X2 isoform I; purinergic receptor P2X, ligand gated ion channel, 2
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
41,370 Da
OMIM
600844
3D Structure
ModBase 3D Structure for Q9UBL9
Immunogen
E Coli-derived human P2X2 recombinant protein (Position: D139-L471). Human P2X2 shares 84% amino acid (aa) sequence identity with both mouse and rat P2X2.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-P2X2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-P2X2 antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-P2X2 antibody

Anti- P2X2 Picoband antibody, MBS178008, Western blotting
All lanes: Anti P2X2 (MBS178008) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: Human Placenta Tissue Lysate at 50ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: SHG Whole Cell Lysate at 40ug
Lane 6: NEURO Whole Cell Lysate at 40ug
Lane 7: 22RV1 Whole Cell Lysate at 40ug
Lane 8: U87 Whole Cell Lysate at 40ug
Predicted bind size: 52KD
Observed bind size: 60KD
Anti-P2X2 Polyclonal Antibody – Cat# MBS178008

Immunohistochemistry (IHC) of anti-P2X2 antibody

Anti- P2X2 Picoband antibody, MBS178008, IHC(P)
IHC(P): Human Lung Cancer Tissue
Anti-P2X2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178008

Product References and Citations for anti-P2X2 antibody

1. Housley, G. D., Morton-Jones, R., Vlajkovic, S. M., Telang, R. S., Paramananthasivam, V., Tadros, S. F., Wong, A. C. Y., Froud, K. E., Cederholm, J. M. E., Sivakumaran, Y., Snguanwongchai, P., Khakh, B. S., Cockayne, D. A., Thorne, P. R., Ryan, A. F. ATP-gated ion channels mediate adaptation to elevated sound levels. Proc. Nat. Acad. Sci. 110: 7494-7499, 2013. 2. Yan, D., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sirmaci, A., Fujikawa, T., Wong, A. C. Y., Loh, T. L., Du, L., Grati, M., Vlajkovic, S. M., and 10 others. Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc. Nat. Acad. Sci. 110: 2228-2233, 2013. 3. Yu, N., Zhao, H.-B. ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitance. Pflugers Arch. 457: 453-461, 2008.

Other Notes

Small volumes of anti-P2X2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for P2X2 purchase

MBS178008 is an antibody targeting P2X2. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for P2X2. It may not necessarily be applicable to this product.

NCBI GI #
531990826
NCBI GeneID
22953
NCBI Accession #
NP_001269093.1
UniProt Primary Accession #
Q9UBL9
UniProt Secondary Accession #
Q6V9R6; Q9NR37; Q9NR38; Q9UHD5; Q9UHD6; Q9UHD7; A6NGB4; A6NH93; A6NHC2; A6NHU3; A6NIG9
UniProt Related Accession #
Q9UBL9
GenBank Nucleotide #
NM_001282164.1
NCBI Official Full Name
P2X purinoceptor 2 isoform J
NCBI Official Synonym Full Names
purinergic receptor P2X 2
NCBI Official Symbol
P2RX2
NCBI Official Synonym Symbols
P2X2; DFNA41
UniProt Protein Name
P2X purinoceptor 2
UniProt Synonym Protein Names
ATP receptor; Purinergic receptor
Protein Family
P2X purinoceptor
UniProt Gene Name
P2RX2
UniProt Synonym Gene Names
P2X2; P2X2
UniProt Entry Name
P2RX2_HUMAN
NCBI Protein Information
P2X purinoceptor 2

NCBI Summary for P2X2

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
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UniProt Comments for P2X2

P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: apical plasma membrane; integral to nuclear inner membrane; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; ATP-gated cation channel activity; identical protein binding; ligand-gated ion channel activity; purinergic nucleotide receptor activity

Biological Process: behavioral response to pain; blood coagulation; detection of hypoxic conditions in blood by carotid body chemoreceptors; neuromuscular junction development; neuromuscular synaptic transmission; peristalsis; positive regulation of calcium-mediated signaling; protein homooligomerization; response to ATP; response to carbohydrate stimulus; response to hypoxia; sensory perception of sound; sensory perception of taste; skeletal muscle fiber development; urinary bladder smooth muscle contraction

Disease: Deafness, Autosomal Dominant 41
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Research Articles on P2X2

1. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-P2X2 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram

Diseases associated with anti-P2X2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >16 publications with P2X2 and Disease Models, Animal
 Inflammation Antibodies  >14 publications with P2X2 and Inflammation
 Hyperalgesia Antibodies  >10 publications with P2X2 and Hyperalgesia
 Peripheral Nervous System Diseases Antibodies  >7 publications with P2X2 and Peripheral Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with P2X2 and Kidney Diseases
 Chromosome Aberrations Antibodies  >2 publications with P2X2 and Chromosome Aberrations
 Nerve Degeneration Antibodies  >2 publications with P2X2 and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >2 publications with P2X2 and Cardiovascular Diseases
 Epilepsy Antibodies  >2 publications with P2X2 and Epilepsy
 Neurobehavioral Manifestations Antibodies  >1 publications with P2X2 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-P2X2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >41 publications with P2X2 and Kidney
 Testis Antibodies  >1 publications with P2X2 and Testis
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