p300 Antibody – Rabbit Polyclonal

p300: a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2.

Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: chromosome; cytosol; histone acetyltransferase complex; nucleoplasm; nucleus; transcription factor complex

Molecular Function: acetyltransferase activity; activating transcription factor binding; androgen receptor binding; beta-catenin binding; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA binding; histone acetyltransferase activity; histone butyryltransferase activity; histone crotonyltransferase activity; lysine N-acetyltransferase activity; nuclear hormone receptor binding; p53 binding; peptide butyryltransferase activity; peptide N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; protein C-terminus binding; protein propionyltransferase activity; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups; zinc ion binding

Biological Process: apoptosis; B cell differentiation; beta-catenin-TCF complex assembly; cellular response to UV; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; fat cell differentiation; heart development; histone acetylation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; lung development; macrophage derived foam cell differentiation; N-terminal peptidyl-lysine acetylation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch signaling pathway; organ morphogenesis; peptidyl-lysine butyrylation; peptidyl-lysine crotonylation; peptidyl-lysine propionylation; platelet formation; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of protein binding; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein amino acid acetylation; protein destabilization; protein deubiquitination; protein stabilization; regulation of autophagy; regulation of cell cycle; regulation of cellular response to heat; regulation of megakaryocyte differentiation; regulation of transcription, DNA-templated; regulation of tubulin deacetylation; response to estrogen; response to hypoxia; skeletal muscle tissue development; somitogenesis; stimulatory C-type lectin receptor signaling pathway; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process

Disease: Colorectal Cancer; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2