Peroxiredoxin 1 (PRDX1) Antibody – Rabbit Polyclonal

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression.

Protein type: Oxidoreductase; Nuclear receptor co-regulator; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: cytoplasm; cytosol; extracellular space; melanosome; mitochondrion; myelin sheath; nucleus

Molecular Function: identical protein binding; peroxidase activity; protein binding; thioredoxin peroxidase activity

Biological Process: cell proliferation; erythrocyte homeostasis; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; regulation of NF-kappaB import into nucleus; regulation of stress-activated MAPK cascade; removal of superoxide radicals; response to reactive oxygen species; retinal homeostasis; skeletal development