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PINX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9233433

MBS9233433 is an antibody targeting PINX1. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to PINX1 More details

$475 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PINX1, Polyclonal Antibody
Full Product Name
Anti-PINX1 Antibody
Product Gene Name
anti-PINX1 antibody
Product Synonym Names
LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
19,714 Da
OMIM
606505
3D Structure
ModBase 3D Structure for Q96BK5
Applications Tested/Suitable for anti-PINX1 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Wester Blot (WB) of anti-PINX1 antibody

Dilution: WB 1/500 - 1/1000
Western blot analysis of PINX1 expression in rat heart (A), rat muscle (B), rat brain (C) whole cell lysates.
Rabbit Anti-PINX1 Polyclonal Antibody – Cat# MBS9233433

Immunohistochemistry (IHC) of anti-PINX1 antibody

Dilution: IH 1/50 - 1/200
Immunohistochemical analysis of PINX1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-PINX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9233433

Other Notes

Small volumes of anti-PINX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PINX1. It may not necessarily be applicable to this product.

NCBI GI #
547234890
NCBI GeneID
54984
NCBI Accession #
NP_001271285.1
UniProt Primary Accession #
Q96BK5
UniProt Secondary Accession #
Q548A5; Q6QWG9; Q7Z7J8; Q96QD7; Q9HBU7; Q9NWW2; B2R9B1
UniProt Related Accession #
Q96BK5
GenBank Nucleotide #
NM_001284356.1
NCBI Official Full Name
PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NCBI Official Synonym Full Names
PIN2/TERF1 interacting, telomerase inhibitor 1
NCBI Official Symbol
PINX1
NCBI Official Synonym Symbols
LPTL; LPTS
UniProt Protein Name
PIN2/TERF1-interacting telomerase inhibitor 1
UniProt Synonym Protein Names
Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Protein Family
PIN2/TERF1-interacting telomerase inhibitor
UniProt Gene Name
PINX1
UniProt Synonym Gene Names
LPTL; LPTS
UniProt Entry Name
PINX1_HUMAN
NCBI Protein Information
PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein; PIN2 interacting protein 1; PIN2-interacting protein 1; TRF1-interacting protein 1; hepatocellular carcinoma-related putative tumor suppressor; liver-related putative tumor suppressor; pin2-i

UniProt Comments for PINX1

PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Inhibitor; Nucleolus

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: nucleoplasm; kinetochore; nuclear chromosome; chromosome, telomeric region; mitochondrion; intracellular membrane-bound organelle; cytoplasm; nucleolus; spindle; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; negative regulation of telomerase activity; regulation of telomerase activity; telomere maintenance via telomerase; mitotic metaphase plate congression
Show more

Research Articles on PINX1

1. Data confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PINX1 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram

Diseases associated with anti-PINX1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with PINX1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >7 publications with PINX1 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with PINX1 and Cell Transformation, Neoplastic
 Genital Diseases, Male Antibodies  >2 publications with PINX1 and Genital Diseases, Male
 Cardiovascular Diseases Antibodies  >2 publications with PINX1 and Cardiovascular Diseases
 Uterine Cervical Neoplasms Antibodies  >2 publications with PINX1 and Uterine Cervical Neoplasms
 Fetal Death Antibodies  >1 publications with PINX1 and Fetal Death
 Neoplasm Metastasis Antibodies  >1 publications with PINX1 and Neoplasm Metastasis
 Ovarian Diseases Antibodies  >1 publications with PINX1 and Ovarian Diseases

Organs/Tissues associated with anti-PINX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with PINX1 and Liver
 Stomach Antibodies  >6 publications with PINX1 and Stomach
 Lymph Antibodies  >4 publications with PINX1 and Lymph
 Lymph Node Antibodies  >4 publications with PINX1 and Lymph Node
 Brain Antibodies  >4 publications with PINX1 and Brain
 Embryonic Tissue Antibodies  >3 publications with PINX1 and Embryonic Tissue
 Lung Antibodies  >2 publications with PINX1 and Lung
 Prostate Antibodies  >2 publications with PINX1 and Prostate
 Ovary Antibodies  >1 publications with PINX1 and Ovary
 Heart Antibodies  >1 publications with PINX1 and Heart
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