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PIP4K2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9132428
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The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PIP4K2B, Polyclonal Antibody
Full Product Name
PIP4K2B Polyclonal Antibody
Product Gene Name
anti-PIP4K2B antibody
Product Synonym Names
PIP4K2B; PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PIP5P4KB; phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 50% Glycerol, pH 7.3
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
Calculated MW: 32kDa/47kDa
Observed MW: 47kDa
OMIM
U85245 mRNA
3D Structure
ModBase 3D Structure for P78356
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PIP4K2B (NP_003550.1).

Product Categories/Family for anti-PIP4K2B antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PIP4K2B antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PIP4K2B antibody
WB: 1:500 - 1:2000
IF: 1:50 - 1:100

Western Blot (WB) of anti-PIP4K2B antibody

Western blot analysis of extracts of various cell lines, using PIP4K2B antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
Rabbit Anti-PIP4K2B Polyclonal Antibody – Cat# MBS9132428

Immunofluorescence (IF) of anti-PIP4K2B antibody

Immunofluorescence analysis of A549 cells using PIP4K2B antibody. Blue: DAPI for nuclear staining.
Rabbit Anti-PIP4K2B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9132428

Other Notes

Small volumes of anti-PIP4K2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIP4K2B purchase

MBS9132428 is an antibody targeting PIP4K2B. Also known as PIP4K2B Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIP4K2B. It may not necessarily be applicable to this product.

NCBI GI #
47605991
NCBI GeneID
8396
NCBI Accession #
P78356.1
UniProt Primary Accession #
P78356
UniProt Secondary Accession #
Q5U0E8; Q8TBP2
UniProt Related Accession #
P78356
NCBI Official Full Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
NCBI Official Synonym Full Names
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
NCBI Official Symbol
PIP4K2B
NCBI Official Synonym Symbols
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta
UniProt Protein Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
UniProt Synonym Protein Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta
Protein Family
Phosphatidylinositol 5-phosphate 4-kinase
UniProt Gene Name
PIP4K2B
UniProt Synonym Gene Names
PIP5K2B; PI(5)P 4-kinase type II beta; PIP4KII-beta
NCBI Protein Information
phosphatidylinositol 5-phosphate 4-kinase type-2 beta

UniProt Comments for PIP4K2B

PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: autophagic vacuole; cytosol; nucleoplasm

Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding; protein homodimerization activity; receptor signaling protein activity

Biological Process: cell surface receptor linked signal transduction; phosphatidylinositol biosynthetic process; phospholipid metabolic process; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade
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Research Articles on PIP4K2B

1. Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PIP4K2B antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-PIP4K2B antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with PIP4K2B and Breast Neoplasms
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