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PLCD4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9434187

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4, 5-bisphosphate into two intracellular second messengers, inositol 1, 4,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLCD4, Polyclonal Antibody
Full Product Name
PLCD4 Polyclonal Antibody
Product Gene Name
anti-PLCD4 antibody
Product Synonym Names
PLCD4; phospholipase C delta 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 50% glycerol, pH7.4
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
31,448 Da
OMIM
605939
3D Structure
ModBase 3D Structure for Q9BRC7
Immunogen
Recombinant fusion protein of human PLCD4 (NP_116115.1).
Conjugation
Unconjugated

Product Categories/Family for anti-PLCD4 antibody

Total protein Ab
Applications Tested/Suitable for anti-PLCD4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PLCD4 antibody
WB: 1:500-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-PLCD4 antibody

Western blot analysis of extracts of various cell lines, using PLCD4 antibody.
Rabbit Anti-PLCD4 Polyclonal Antibody – Cat# MBS9434187

Immunofluorescence (IF) of anti-PLCD4 antibody

Immunofluorescence analysis of U2OS cells using PLCD4 antibody.
Rabbit Anti-PLCD4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9434187

Other Notes

Small volumes of anti-PLCD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLCD4 purchase

MBS9434187 is an antibody targeting PLCD4. Also known as PLCD4 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCD4. It may not necessarily be applicable to this product.

NCBI GI #
14249340
NCBI GeneID
84812
NCBI Accession #
NP_116115.1
UniProt Primary Accession #
Q9BRC7
UniProt Secondary Accession #
Q53FS8
UniProt Related Accession #
Q9BRC7
GenBank Nucleotide #
NM_032726.3
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
NCBI Official Synonym Full Names
phospholipase C, delta 4
NCBI Official Symbol
PLCD4
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
Protein Family
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name
PLCD4
UniProt Synonym Gene Names
hPLCD4; PLC-delta-4
UniProt Entry Name
PLCD4_HUMAN
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

NCBI Summary for PLCD4

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
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UniProt Comments for PLCD4

PLCD4: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nuclear membrane; endoplasmic reticulum; cytoplasm; plasma membrane

Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity

Biological Process: acrosome reaction; phosphatidylinositol metabolic process; lipid catabolic process
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Research Articles on PLCD4

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLCD4 antibody

 Reference Product  PubMed Publications
 DGKI antibody  >1 publications with PLCD4 and DGKI
 DGKZ antibody  >1 publications with PLCD4 and DGKZ

Pathways associated with anti-PLCD4 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-PLCD4 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with PLCD4 and Breast Neoplasms
 Arrhythmias, Cardiac Antibodies  >1 publications with PLCD4 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >1 publications with PLCD4 and Hypertrophy

Organs/Tissues associated with anti-PLCD4 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with PLCD4 and Testis
 Liver Antibodies  >2 publications with PLCD4 and Liver
 Heart Antibodies  >1 publications with PLCD4 and Heart
 Embryonic Tissue Antibodies  >1 publications with PLCD4 and Embryonic Tissue
 Muscle Antibodies  >1 publications with PLCD4 and Muscle
 Brain Antibodies  >1 publications with PLCD4 and Brain
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