Plexin A1 (PLXNA1) Antibody – Rabbit Polyclonal

PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: extracellular exosome; integral component of membrane; plasma membrane

Molecular Function: receptor activity; semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; multicellular organism development; regulation of axon extension involved in axon guidance; regulation of smooth muscle cell migration; semaphorin-plexin signaling pathway