POLR2L Antibody – Rabbit Polyclonal

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

POLR2L: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.

Protein type: EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; DNA-binding; Transferase

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase II, core complex; cytosol; nucleus; DNA-directed RNA polymerase I complex

Molecular Function: DNA binding; zinc ion binding; DNA-directed RNA polymerase activity

Biological Process: transcription from RNA polymerase II promoter; termination of RNA polymerase III transcription; viral reproduction; positive regulation of viral transcription; somatic stem cell maintenance; regulation of gene expression, epigenetic; transcription from RNA polymerase III promoter; mRNA capping; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; positive regulation of interferon type I production; RNA elongation from RNA polymerase III promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase I promoter; RNA splicing; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; DNA repair; nuclear mRNA splicing, via spliceosome; nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; innate immune response; gene expression; transcription initiation from RNA polymerase I promoter