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PP2Cepsilon Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9244942

Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. More details

$475 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PP2Cepsilon, Polyclonal Antibody
Full Product Name
PP2Cepsilon Polyclonal Antibody
Product Gene Name
anti-PP2Cepsilon antibody
Product Synonym Gene Name
PPM1L
Product Synonym Names
PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
41,053 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (160473996..160788817). Location: 3q26.1
OMIM
611931
3D Structure
ModBase 3D Structure for Q5SGD2
Applications Tested/Suitable for anti-PP2Cepsilon antibody
Western Blot (WB)

Wester Blot (WB) of anti-PP2Cepsilon antibody

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Rabbit Anti-PP2Cepsilon Polyclonal Antibody – Cat# MBS9244942

Other Notes

Small volumes of anti-PP2Cepsilon antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PP2Cepsilon purchase

MBS9244942 is an antibody targeting PP2Cepsilon. Also known as PP2Cepsilon Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PP2Cepsilon. It may not necessarily be applicable to this product.

NCBI GI #
63003905
NCBI GeneID
151742
NCBI Accession #
NP_640338.2
UniProt Primary Accession #
Q5SGD2
UniProt Secondary Accession #
Q2M3J2; Q96NM7
UniProt Related Accession #
Q5SGD2
GenBank Nucleotide #
NM_139245.2
NCBI Official Full Name
protein phosphatase 1L
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent, 1L
NCBI Official Symbol
PPM1L
NCBI Official Synonym Symbols
PP2CE; PPM1-LIKE; PP2C-epsilon
UniProt Protein Name
Protein phosphatase 1L
UniProt Synonym Protein Names
Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon
UniProt Gene Name
PPM1L
UniProt Synonym Gene Names
PP2CE; PP2C-epsilon
UniProt Entry Name
PPM1L_HUMAN
NCBI Protein Information
protein phosphatase 1L; PP2C epsilon; Protein phosphatase 2C epsilon isoform; protein phosphatase 2C isoform epsilon

NCBI Summary for PP2Cepsilon

PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).[supplied by OMIM, Apr 2008]
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UniProt Comments for PP2Cepsilon

PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: metal ion binding; protein serine/threonine phosphatase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway; MAPKKK cascade; protein amino acid dephosphorylation
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Research Articles on PP2Cepsilon

1. identified ACBD3 as an interacting partner of PPM1L, and showed that this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PP2Cepsilon antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with anti-PP2Cepsilon antibody

 Disease Name  Pubmed Publications
 Adenoma Antibodies  >1 publications with PP2Cepsilon and Adenoma
 Neoplasms Antibodies  >1 publications with PP2Cepsilon and Neoplasms
 Obesity Antibodies  >1 publications with PP2Cepsilon and Obesity

Organs/Tissues associated with anti-PP2Cepsilon antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with PP2Cepsilon and Liver
 Connective Tissue Antibodies  >1 publications with PP2Cepsilon and Connective Tissue
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