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RAB6A / RAB6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249883

RAB6A Antibody, Rab GTPase Antibody, Rab-6 Antibody, RAB6 Antibody, Ras-related protein rab-6 Antibody, RAB6A' Antibody, Ras-related protein Rab-6A Antibody Description: RAB6A / RAB6 is a member of the RAB family, which belongs to the small GTPase… More details

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Product Overview

Product Name
RAB6A / RAB6, Polyclonal Antibody
Full Product Name
Anti-RAB6A / RAB6 Antibody (aa1-208) IHC-plus
Product Gene Name
anti-RAB6A / RAB6 antibody
Product Synonym Names
Rabbit Polyclonal (IgG) to Human RAB6A / RAB6; Human RAB6A / RAB6; Rab GTPase; Rab-6; RAB6; Ras-related protein rab-6; RAB6A'; Ras-related protein Rab-6A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity purified
Concentration
0.63 mg/ml (lot specific)
Specificity
Human RAB6
Preparation and Storage
Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.
Molecular Weight
19,935 Da
OMIM
179513
3D Structure
ModBase 3D Structure for P20340
Immunogen
RAB6A / RAB6 antibody was raised against recombinant fragment corresponding to a region within amino acids 1 and 208 of RAB6A (SwissProt P20340). Percent identity by BLAST analysis: Human (100%); Bovine (98%); Chicken, Pig, Rat (97%); Xenopus (96%); Zebrafish (85%).
Immunogen Description
Recombinant fragment corresponding to a region within amino acids 1 and 208 of RAB6A (SwissProt P20340). Percent identity by BLAST analysis: Human (100%); Bovine (98%); Chicken, Pig, Rat (97%); Xenopus (96%); Zebrafish (85%).
Immunogen Type
Recombinant protein
Antigen Modification
aa1-208
Target Species
Human
Applications Tested/Suitable for anti-RAB6A / RAB6 antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-RAB6A / RAB6 antibody
ICC (1:100 - 1:1000)
IHC-P (7.5 ug/ml)
WB (1:500 - 1:3000)

Immunohistochemistry (IHC) of anti-RAB6A / RAB6 antibody

Anti-RAB6A / RAB6 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
Rabbit Anti-RAB6A / RAB6 Polyclonal Antibody – Cat# MBS249883

Immunocytochemistry (ICC) of anti-RAB6A / RAB6 antibody

Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa using RAB6A antibody (Green) at 1:1000 dilution. Alpha-tubulin filaments were labeled with alpha-tubulin antibody (Red) at 1:2000.
Rabbit Anti-RAB6A / RAB6 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS249883

Western Blot (WB) of anti-RAB6A / RAB6 antibody

Sample (50 ug of whole cell lysate). A: Rat brain lysate/extract. 12% SDS PAGE. RAB6 antibody diluted at 1:1000.
Rabbit Anti-RAB6A / RAB6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249883

Western Blot (WB) of anti-RAB6A / RAB6 antibody

Sample (50 ug of whole cell lysate). A: Mouse brain lysate/extract. 12% SDS PAGE. RAB6 antibody diluted at 1:1000.
Rabbit Anti-RAB6A / RAB6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249883

Western Blot (WB) of anti-RAB6A / RAB6 antibody

Sample (30 ug of whole cell lysate). A: H1299. 12% SDS PAGE. RAB6 antibody diluted at 1:1000.
Rabbit Anti-RAB6A / RAB6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249883

Other Notes

Small volumes of anti-RAB6A / RAB6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAB6A / RAB6 purchase

MBS249883 is an antibody targeting RAB6A / RAB6. Also known as Anti-RAB6A / RAB6 Antibody (aa1-208) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RAB6A / RAB6. It may not necessarily be applicable to this product.

NCBI GI #
19923231
NCBI GeneID
5870
NCBI Accession #
NP_002860.2
UniProt Primary Accession #
P20340
UniProt Secondary Accession #
Q1W5D8; Q5U0A8; Q9UBE4; A8K133; B7Z772; F5H668
UniProt Related Accession #
P20340
GenBank Nucleotide #
NM_002869.4
NCBI Official Full Name
ras-related protein Rab-6A isoform a
NCBI Official Synonym Full Names
RAB6A, member RAS oncogene family
NCBI Official Symbol
RAB6A
NCBI Official Synonym Symbols
RAB6
UniProt Protein Name
Ras-related protein Rab-6A
UniProt Gene Name
RAB6A
UniProt Synonym Gene Names
RAB6; Rab-6
UniProt Entry Name
RAB6A_HUMAN
NCBI Protein Information
ras-related protein Rab-6A

NCBI Summary for RAB6A / RAB6

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
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UniProt Comments for RAB6A / RAB6

RAB6A: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rab; Motility/polarity/chemotaxis; G protein, monomeric

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: cytoplasmic vesicle; cytosol; Golgi apparatus; Golgi membrane; membrane; trans-Golgi network

Molecular Function: GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding

Biological Process: antigen processing and presentation; peptidyl-cysteine methylation; protein localization in Golgi apparatus; protein targeting to Golgi; retrograde vesicle-mediated transport, Golgi to ER; small GTPase mediated signal transduction; viral reproduction
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Research Articles on RAB6A / RAB6

1. Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RAB6A / RAB6 antibody

 Reference Product  PubMed Publications
 BICD2 antibody  >5 publications with RAB6A / RAB6 and BICD2
 KIF20A antibody  >3 publications with RAB6A / RAB6 and KIF20A
 BICD1 antibody  >2 publications with RAB6A / RAB6 and BICD1
 GCC2 antibody  >1 publications with RAB6A / RAB6 and GCC2

Pathways associated with anti-RAB6A / RAB6 antibody

 Products by Pathway  Pathway Diagram
 Pre-NOTCH Expression And Processing Pathway antibodies  Pre-NOTCH Expression And Processing Pathway Diagram
 Pre-NOTCH Processing In Golgi Pathway antibodies  Pre-NOTCH Processing In Golgi Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram

Diseases associated with anti-RAB6A / RAB6 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with RAB6A / RAB6 and Necrosis
 Neurodegenerative Diseases Antibodies  >2 publications with RAB6A / RAB6 and Neurodegenerative Diseases
 Brain Diseases Antibodies  >2 publications with RAB6A / RAB6 and Brain Diseases
 Atrophy Antibodies  >2 publications with RAB6A / RAB6 and Atrophy
 Prostatic Diseases Antibodies  >1 publications with RAB6A / RAB6 and Prostatic Diseases
 Hepatitis Antibodies  >1 publications with RAB6A / RAB6 and Hepatitis
 Liver Diseases Antibodies  >1 publications with RAB6A / RAB6 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with RAB6A / RAB6 and Kidney Diseases
 Inflammation Antibodies  >1 publications with RAB6A / RAB6 and Inflammation

Organs/Tissues associated with anti-RAB6A / RAB6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with RAB6A / RAB6 and Brain
 Nerve Antibodies  >3 publications with RAB6A / RAB6 and Nerve
 Muscle Antibodies  >2 publications with RAB6A / RAB6 and Muscle
 Liver Antibodies  >2 publications with RAB6A / RAB6 and Liver
 Prostate Antibodies  >2 publications with RAB6A / RAB6 and Prostate
 Placenta Antibodies  >2 publications with RAB6A / RAB6 and Placenta
 Eye Antibodies  >1 publications with RAB6A / RAB6 and Eye
 Kidney Antibodies  >1 publications with RAB6A / RAB6 and Kidney
 Intestine Antibodies  >1 publications with RAB6A / RAB6 and Intestine
 Testis Antibodies  >1 publications with RAB6A / RAB6 and Testis
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