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RASD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9604857

Function: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RASD2, Polyclonal Antibody
Full Product Name
RASD2 Antibody
Product Gene Name
anti-RASD2 antibody
Product Synonym Names
GTP binding protein Rhes; GTP-binding protein Rhes; MGC:4834; OTTHUMP00000197925; Ras homolog enriched in striatum; RASD 2; RASD family member 2; RASD2; Rhes; RHES_HUMAN; TEM 2; TEM2; Tumor endothelial marker 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
RASD2 antibody detects endogenous levels of total RASD2
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
RASD2 peptide (MBS9623574) is used for blocking the activity of RASD2 antibody (MBS9604857)
Molecular Weight
Observed: 35 kD
Predicted: 31 kDa
3D Structure
ModBase 3D Structure for Q96D21
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane
Tissue Specificity
Pancreatic endocrine cells (islets of Langerhans).
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (88%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RASD2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-RASD2 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Immunofluorescence (IF) of anti-RASD2 antibody

MBS9604857 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-RASD2 Polyclonal Antibody – Cat# MBS9604857

Western Blot (WB) of anti-RASD2 antibody

Western blot analysis of extracts from Jurkat cells, using RASD2 antibody.
Rabbit Anti-RASD2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9604857

Other Notes

Small volumes of anti-RASD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RASD2 purchase

MBS9604857 is an antibody targeting RASD2. Also known as RASD2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RASD2. It may not necessarily be applicable to this product.

NCBI GI #
22027486
NCBI GeneID
23551
NCBI Accession #
NP_055125.2
UniProt Primary Accession #
Q96D21
UniProt Secondary Accession #
O95520; Q5THY8
UniProt Related Accession #
Q96D21
GenBank Nucleotide #
NM_014310.4
NCBI Official Full Name
GTP-binding protein Rhes
NCBI Official Synonym Full Names
RASD family member 2
NCBI Official Symbol
RASD2
NCBI Official Synonym Symbols
Rhes; TEM2
UniProt Protein Name
GTP-binding protein Rhes
UniProt Synonym Protein Names
Ras homolog enriched in striatum; Tumor endothelial marker 2
Protein Family
GTP-binding protein
UniProt Gene Name
RASD2
UniProt Synonym Gene Names
TEM2
NCBI Protein Information
GTP-binding protein Rhes

NCBI Summary for RASD2

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
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UniProt Comments for RASD2

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Research Articles on RASD2

1. Study demonstrated that variation in the gene coding for RASD2 (rs6518956) affects in vivo prefrontal and striatal phenotypes in healthy human subjects that are relevant to schizophrenia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-RASD2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with RASD2 and Disease Models, Animal
 Neoplasms Antibodies  >2 publications with RASD2 and Neoplasms
 Learning Disorders Antibodies  >2 publications with RASD2 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with RASD2 and Memory Disorders

Organs/Tissues associated with anti-RASD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with RASD2 and Brain
 Liver Antibodies  >1 publications with RASD2 and Liver
 Intestine Antibodies  >1 publications with RASD2 and Intestine
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