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RB6I2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603940

Function: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RB6I2, Polyclonal Antibody
Full Product Name
RB6I2 Antibody
Product Gene Name
anti-RB6I2 antibody
Product Synonym Gene Name
ERC1
Product Synonym Names
Cast 2; CAST2; CAZ associated structural protein 2; Elks; ELKS/RAB6 interacting/CAST family member 1; ELKS/RAB6-interacting/CAST family member 1; ERC 1; ERC protein 1; ERC-1; Erc1; ERC1 protein; KIAA1081; MGC12974; RAB6 interacting protein 2; RAB6-interacting protein 2; RAB6IP2; RB6I2_HUMAN
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
RB6I2 antibody detects endogenous levels of total RB6I2
Antibody/Peptide Pairs
RB6I2 peptide (MBS9622657) is used for blocking the activity of RB6I2 antibody (MBS9603940)
Molecular Weight
Predicted: 129 kDa
3D Structure
ModBase 3D Structure for Q8IUD2
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Cytoplasm. Membrane. Golgi Apparatus Membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
Tissue Specificity
Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (90%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RB6I2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RB6I2 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-RB6I2 antibody

Western blot analysis of RB6I2 expression in HEK293 cells, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-RB6I2 Polyclonal Antibody – Cat# MBS9603940

Other Notes

Small volumes of anti-RB6I2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RB6I2 purchase

MBS9603940 is an antibody targeting RB6I2. Also known as RB6I2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RB6I2. It may not necessarily be applicable to this product.

NCBI GI #
38045896
NCBI GeneID
23085
NCBI Accession #
NP_829883.1
UniProt Primary Accession #
Q8IUD2
UniProt Secondary Accession #
Q6NVK2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; A2RU77; A7E295; D3DUP7; D3DUP8
UniProt Related Accession #
Q8IUD2
GenBank Nucleotide #
NM_178039.3
NCBI Official Full Name
ELKS/Rab6-interacting/CAST family member 1 isoform delta
NCBI Official Synonym Full Names
ELKS/RAB6-interacting/CAST family member 1
NCBI Official Symbol
ERC1
NCBI Official Synonym Symbols
ELKS; Cast2; ERC-1; RAB6IP2
UniProt Protein Name
ELKS/Rab6-interacting/CAST family member 1
UniProt Synonym Protein Names
Rab6-interacting protein 2
UniProt Gene Name
ERC1
UniProt Synonym Gene Names
ELKS; KIAA1081; RAB6IP2; ERC-1
NCBI Protein Information
ELKS/Rab6-interacting/CAST family member 1

NCBI Summary for RB6I2

The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for RB6I2

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
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Research Articles on RB6I2

1. ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RB6I2 antibody

 Reference Product  PubMed Publications
 RIMS1 antibody  >2 publications with RB6I2 and RIMS1
 PPFIA1 antibody  >1 publications with RB6I2 and PPFIA1

Pathways associated with anti-RB6I2 antibody

 Products by Pathway  Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram

Diseases associated with anti-RB6I2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RB6I2 and Neoplasms
 Liver Diseases Antibodies  >2 publications with RB6I2 and Liver Diseases
 Lung Neoplasms Antibodies  >1 publications with RB6I2 and Lung Neoplasms
 Leukemia, Myeloid Antibodies  >1 publications with RB6I2 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >1 publications with RB6I2 and Leukemia, Myeloid, Acute
 Leukemia, Monocytic, Acute Antibodies  >1 publications with RB6I2 and Leukemia, Monocytic, Acute
 Carcinoma, Papillary Antibodies  >1 publications with RB6I2 and Carcinoma, Papillary
 Recurrence Antibodies  >1 publications with RB6I2 and Recurrence
 Translocation, Genetic Antibodies  >1 publications with RB6I2 and Translocation, Genetic
 Breast Neoplasms Antibodies  >1 publications with RB6I2 and Breast Neoplasms

Organs/Tissues associated with anti-RB6I2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with RB6I2 and Brain
 Blood Antibodies  >2 publications with RB6I2 and Blood
 Thyroid Antibodies  >1 publications with RB6I2 and Thyroid
 Bone Antibodies  >1 publications with RB6I2 and Bone
 Liver Antibodies  >1 publications with RB6I2 and Liver
 Muscle Antibodies  >1 publications with RB6I2 and Muscle
 Kidney Antibodies  >1 publications with RB6I2 and Kidney
 Lung Antibodies  >1 publications with RB6I2 and Lung
 Embryonic Tissue Antibodies  >1 publications with RB6I2 and Embryonic Tissue
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