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RCC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS129737
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CHC1, also named as RCC1, promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1… More details

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Product Overview

Online Datasheet in PDF
Product Name
RCC1, Polyclonal Antibody
Full Product Name
RCC1 Polyclonal Antibody
Product Gene Name
anti-RCC1 antibody
Product Synonym Names
CHC1; RCC1-I; SNHG3-RCC1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
421
OMIM
179710
3D Structure
ModBase 3D Structure for P18754
Species
Human
Immunogen
Recombinant protein of human RCC1
Calculated Molecular Weight
45kDa

Product Categories/Family for anti-RCC1 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RCC1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-RCC1 antibody
WB: 1:500 - 1:2000
IHC: 1:20 - 1:200
IP: 1:20 - 1:100

Western Blot (WB) of anti-RCC1 antibody

Western blot analysis of extracts of various cell lines, using RCC1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
Rabbit Anti-RCC1 Polyclonal Antibody – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat lung using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat liver using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat testis using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat brain using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat spleen using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat kidney using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded rat heart using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Immunohistochemistry (IHC) of anti-RCC1 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using RCC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-RCC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS129737

Other Notes

Small volumes of anti-RCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RCC1 purchase

MBS129737 is an antibody targeting RCC1. Also known as RCC1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RCC1. It may not necessarily be applicable to this product.

NCBI GI #
132170
NCBI GeneID
1104
NCBI Accession #
P18754.1
UniProt Primary Accession #
P18754
UniProt Secondary Accession #
Q16269; Q6NT97
UniProt Related Accession #
P18754
NCBI Official Full Name
Regulator of chromosome condensation
NCBI Official Synonym Full Names
regulator of chromosome condensation 1
NCBI Official Symbol
RCC1
NCBI Official Synonym Symbols
CHC1; RCC1-I; SNHG3-RCC1
UniProt Protein Name
Regulator of chromosome condensation
UniProt Synonym Protein Names
Cell cycle regulatory protein; Chromosome condensation protein 1
Protein Family
Protein
UniProt Gene Name
RCC1
UniProt Synonym Gene Names
CHC1
UniProt Entry Name
RCC1_HUMAN
NCBI Protein Information
regulator of chromosome condensation; SNHG3-RCC1 readthrough; cell cycle regulatory protein; guanine nucleotide-releasing protein

UniProt Comments for RCC1

RCC1: a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Ras; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: nucleoplasm; nuclear membrane; condensed nuclear chromosome; cytoplasm; nuclear chromatin; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; Ran guanyl-nucleotide exchange factor activity; histone binding; chromatin binding

Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; cell division; regulation of mitosis; spindle assembly; G1/S transition of mitotic cell cycle; chromosome segregation
Show more

Research Articles on RCC1

1. RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RCC1 antibody

 Reference Product  PubMed Publications
 RAN antibody  >225 publications with RCC1 and RAN
 RANBP1 antibody  >34 publications with RCC1 and RANBP1
 RANGAP1 antibody  >26 publications with RCC1 and RANGAP1
 MYC antibody  >9 publications with RCC1 and MYC
 PCNA antibody  >3 publications with RCC1 and PCNA
 KPNA4 antibody  >2 publications with RCC1 and KPNA4
 RANBP3 antibody  >2 publications with RCC1 and RANBP3
 KPNB1 antibody  >2 publications with RCC1 and KPNB1
 VRK1 antibody  >1 publications with RCC1 and VRK1

Pathways associated with anti-RCC1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Interactions Of Rev With Host Cellular Proteins Pathway antibodies  Interactions Of Rev With Host Cellular Proteins Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
 Nuclear Import Of Rev Protein Pathway antibodies  Nuclear Import Of Rev Protein Pathway Diagram
 Rev-mediated Nuclear Export Of HIV RNA Pathway antibodies  Rev-mediated Nuclear Export Of HIV RNA Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-RCC1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with RCC1 and Adenocarcinoma
 Kidney Diseases Antibodies  >4 publications with RCC1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >4 publications with RCC1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with RCC1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with RCC1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with RCC1 and Liver Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with RCC1 and Pancreatic Neoplasms
 Heart Diseases Antibodies  >2 publications with RCC1 and Heart Diseases
 Atrophy Antibodies  >1 publications with RCC1 and Atrophy
 Hypertrophy Antibodies  >1 publications with RCC1 and Hypertrophy

Organs/Tissues associated with anti-RCC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >23 publications with RCC1 and Eye
 Kidney Antibodies  >16 publications with RCC1 and Kidney
 Blood Antibodies  >12 publications with RCC1 and Blood
 Liver Antibodies  >6 publications with RCC1 and Liver
 Vascular Antibodies  >5 publications with RCC1 and Vascular
 Muscle Antibodies  >5 publications with RCC1 and Muscle
 Brain Antibodies  >5 publications with RCC1 and Brain
 Testis Antibodies  >4 publications with RCC1 and Testis
 Nerve Antibodies  >4 publications with RCC1 and Nerve
 Skin Antibodies  >4 publications with RCC1 and Skin
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