RECK Antibody – Rabbit Polyclonal

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. [provided by RefSeq, Jul 2008]

RECK: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Protein type: Membrane protein, GPI anchor; Tumor suppressor

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: membrane; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity

Biological Process: extracellular matrix organization and biogenesis; blood vessel maturation; embryo implantation