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RGS4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2566085

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha… More details

$265 / 0.06 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RGS4, Polyclonal Antibody
Full Product Name
RGS4 Polyclonal Antibody
Product Gene Name
anti-RGS4 antibody
Product Synonym Names
RGS4; RGP4; SCZD9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
23,256 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (163038396..163046592). Location: 1q23.3
OMIM
181500
3D Structure
ModBase 3D Structure for P49798
Immunogen
A synthetic peptide of human RGS4 (NP_0056041)
Conjugation
Unconjugated

Product Categories/Family for anti-RGS4 antibody

Cancer; Cardiovascular; Signal Transduction; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RGS4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-RGS4 antibody
WB: 1:500-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-RGS4 antibody

Western blot analysis of extracts of various cell lines using RGS4 Polyclonal Antibody at dilution of 1:1000.
Rabbit Anti-RGS4 Polyclonal Antibody – Cat# MBS2566085

Immunofluorescence (IF) of anti-RGS4 antibody

Immunofluorescence analysis of C6 cells using RGS4 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-RGS4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2566085

Immunofluorescence (IF) of anti-RGS4 antibody

Immunofluorescence analysis of L929 cells using RGS4 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-RGS4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2566085

Immunofluorescence (IF) of anti-RGS4 antibody

Immunofluorescence analysis of U-2 OS cells using RGS4 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-RGS4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS2566085

Other Notes

Small volumes of anti-RGS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS4 purchase

MBS2566085 is an antibody targeting RGS4. Also known as RGS4 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS4. It may not necessarily be applicable to this product.

NCBI GI #
5032039
NCBI GeneID
5999
NCBI Accession #
NP_005604.1
UniProt Primary Accession #
P49798
UniProt Secondary Accession #
A7XA56; A7XA58; A7XA59; A7YVV7; B1APZ3
UniProt Related Accession #
P49798
GenBank Nucleotide #
NM_005613.5
NCBI Official Full Name
regulator of G-protein signaling 4 isoform 2
NCBI Official Synonym Full Names
regulator of G-protein signaling 4
NCBI Official Symbol
RGS4
NCBI Official Synonym Symbols
RGP4; SCZD9
UniProt Protein Name
Regulator of G-protein signaling 4
Protein Family
Regulator of G-protein signaling
UniProt Gene Name
RGS4
UniProt Synonym Gene Names
RGP4; RGS4
UniProt Entry Name
RGS4_HUMAN
NCBI Protein Information
regulator of G-protein signaling 4; schizophrenia disorder 9

UniProt Comments for RGS4

RGS4: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol

Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity

Biological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity; inactivation of MAPK activity

Disease: Schizophrenia 9
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Research Articles on RGS4

1. dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RGS4 antibody

 Reference Product  PubMed Publications
 DRD3 antibody  >4 publications with RGS4 and DRD3
 ERBB3 antibody  >3 publications with RGS4 and ERBB3
 DRD2 antibody  >3 publications with RGS4 and DRD2
 GNAI2 antibody  >3 publications with RGS4 and GNAI2

Pathways associated with anti-RGS4 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-RGS4 antibody

 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >97 publications with RGS4 and Schizophrenia
 Cardiovascular Diseases Antibodies  >34 publications with RGS4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >27 publications with RGS4 and Nervous System Diseases
 Heart Diseases Antibodies  >23 publications with RGS4 and Heart Diseases
 Neoplasms Antibodies  >21 publications with RGS4 and Neoplasms
 Heart Failure Antibodies  >17 publications with RGS4 and Heart Failure
 Hypertension Antibodies  >11 publications with RGS4 and Hypertension
 Cognition Disorders Antibodies  >10 publications with RGS4 and Cognition Disorders
 Movement Disorders Antibodies  >8 publications with RGS4 and Movement Disorders
 Kidney Diseases Antibodies  >8 publications with RGS4 and Kidney Diseases

Organs/Tissues associated with anti-RGS4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >150 publications with RGS4 and Brain
 Nerve Antibodies  >36 publications with RGS4 and Nerve
 Kidney Antibodies  >31 publications with RGS4 and Kidney
 Vascular Antibodies  >26 publications with RGS4 and Vascular
 Pancreas Antibodies  >10 publications with RGS4 and Pancreas
 Lung Antibodies  >10 publications with RGS4 and Lung
 Embryonic Tissue Antibodies  >9 publications with RGS4 and Embryonic Tissue
 Intestine Antibodies  >9 publications with RGS4 and Intestine
 Eye Antibodies  >8 publications with RGS4 and Eye
 Liver Antibodies  >7 publications with RGS4 and Liver
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