Rabbit Anti-RUSC1 Polyclonal Antibody – Cat# MBS151353

Western blot analysis of RUSC1 in A-20 cell lysate with RUSC1 antibody at 1 μg/mL.

RUSC1 Antibody – Rabbit Polyclonal

Name: RUSC1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS151353
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151353

RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RUSC1, Polyclonal Antibody

Full Product Name

RUSC1 Antibody

Product Gene Name

anti-RUSC1 antibody

Product Synonym Names

RUSC1; NESCA; NESCA; RUN and SH3 domain-containing protein 1; New molecule containing SH3 at the carboxy-terminus; Nesca; RUN and SH3 domain containing 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid

Purity/Purification

RUSC1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Preparation and Storage

RUSC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

RUSC1 peptide (MBS151791) is used for blocking the activity of RUSC1 antibody (MBS151353)

Molecular Weight

85,216 Da

3D Structure

ModBase 3D Structure for Q9BVN2

Conjugate

Unconjugated

Immunogen

RUSC1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RUSC1.

Buffer

RUSC1 Antibody is supplied in PBS containing 0.02% sodium azide.

Applications Tested/Suitable for anti-RUSC1 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-RUSC1 antibody

RUSC1 antibody can be used for detection of RUSC1 by Western blot at 1 mug/mL.

Other Notes

Small volumes of anti-RUSC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RUSC1 purchase

MBS151353 is an antibody targeting RUSC1. Also known as RUSC1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RUSC1. It may not necessarily be applicable to this product.

NCBI GI #

157412245

NCBI GeneID

23623

NCBI Accession #

NP_001098673

UniProt Primary Accession #

Q9BVN2

UniProt Secondary Accession #

Q5T9U9; Q5T9V0; Q5T9V1; Q5T9V2; Q9UPY4; Q9Y4T5; B3KWM9

UniProt Related Accession #

Q9BVN2

GenBank Nucleotide #

NM_001105203.1

NCBI Official Full Name

RUN and SH3 domain-containing protein 1 isoform a

NCBI Official Synonym Full Names

RUN and SH3 domain containing 1

NCBI Official Symbol

RUSC1

NCBI Official Synonym Symbols

NESCA

UniProt Protein Name

RUN and SH3 domain-containing protein 1

UniProt Synonym Protein Names

New molecule containing SH3 at the carboxy-terminus; Nesca

Protein Family

RUN and SH3 domain-containing protein

UniProt Gene Name

RUSC1

UniProt Synonym Gene Names

NESCA; Nesca

UniProt Entry Name

RUSC1_HUMAN

NCBI Protein Information

RUN and SH3 domain-containing protein 1; new molecule containing SH3 at the carboxy-terminus

UniProt Comments for RUSC1

RUSC1: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: microtubule cytoskeleton; Golgi apparatus; postsynaptic membrane; microtubule; postsynaptic density; cytoplasmic membrane-bound vesicle; early endosome; cytoplasm; cytoplasmic vesicle; cell junction; nucleus

Molecular Function: protein binding; SH3/SH2 adaptor activity; actin binding

Biological Process: protein polyubiquitination; positive regulation of signal transduction

Research Articles on RUSC1

1. RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RUSC1 antibody

Reference Product	PubMed Publications
NTRK1 antibody	>2 publications with RUSC1 and NTRK1
TRAF6 antibody	>1 publications with RUSC1 and TRAF6
IKBKG antibody	>1 publications with RUSC1 and IKBKG

Pathways associated with anti-RUSC1 antibody

Products by Pathway	Pathway Diagram
Trk Receptor Signaling Mediated By The MAPK Pathway antibodies	Trk Receptor Signaling Mediated By The MAPK Pathway Diagram

Diseases associated with anti-RUSC1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with RUSC1 and Inflammation

Organs/Tissues associated with anti-RUSC1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with RUSC1 and Brain
Nerve Antibodies	>2 publications with RUSC1 and Nerve
Placenta Antibodies	>2 publications with RUSC1 and Placenta
Kidney Antibodies	>1 publications with RUSC1 and Kidney
Embryonic Tissue Antibodies	>1 publications with RUSC1 and Embryonic Tissue
Bladder Antibodies	>1 publications with RUSC1 and Bladder
Prostate Antibodies	>1 publications with RUSC1 and Prostate
Lung Antibodies	>1 publications with RUSC1 and Lung