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RyR-2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9458709

ryanodine receptor 2 (RYR2), Homo sapiens. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and… More details

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Product Overview

Online Datasheet in PDF
Product Name
RyR-2, Polyclonal Antibody
Full Product Name
RyR-2 (Phospho Ser2808) Polyclonal Antibody
Product Gene Name
anti-RyR-2 antibody
Product Synonym Names
RYR2; Ryanodine receptor 2; RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
Phospho-RyR-2 (S2808) Polyclonal Antibody detects endogenous levels of RyR-2 protein only when phosphorylated at S2808.
Preparation and Storage
Store at -20 degree C for 1 year
Molecular Weight
564,567 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (237205702..237997288). Location: 1q43
OMIM
180902
3D Structure
ModBase 3D Structure for Q92736
Immunogen
The antiserum was produced against synthesized peptide derived from human RyR2 around the phosphorylation site of Ser2808. AA range:2774-2823

Product Categories/Family for anti-RyR-2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-RyR-2 antibody
Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin, section), ELISA (EIA)
Application Notes for anti-RyR-2 antibody
IHC: 1/100-1/300
ELISA: 1/10000

Other Notes

Small volumes of anti-RyR-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RyR-2 purchase

MBS9458709 is an antibody targeting RyR-2. Also known as RyR-2 (Phospho Ser2808) Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RyR-2. It may not necessarily be applicable to this product.

NCBI GI #
112799847
NCBI GeneID
6262
NCBI Accession #
NP_001026.2
UniProt Primary Accession #
Q92736
UniProt Secondary Accession #
Q15411; Q546N8; Q5T3P2
UniProt Related Accession #
Q92736
GenBank Nucleotide #
NM_001035.2
NCBI Official Full Name
ryanodine receptor 2
NCBI Official Synonym Full Names
ryanodine receptor 2 (cardiac)
NCBI Official Symbol
RYR2
NCBI Official Synonym Symbols
RyR; ARVC2; ARVD2; RYR-2; VTSIP
UniProt Protein Name
Ryanodine receptor 2
UniProt Synonym Protein Names
Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
Protein Family
Ryanodine receptor
UniProt Gene Name
RYR2
UniProt Synonym Gene Names
RYR-2; RyR2; hRYR-2
UniProt Entry Name
RYR2_HUMAN
NCBI Protein Information
ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel

NCBI Summary for RyR-2

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
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UniProt Comments for RyR-2

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.

Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Transporter

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: sarcoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; membrane; sarcoplasmic reticulum; plasma membrane; Z disc

Molecular Function: calmodulin binding; calcium-induced calcium release activity; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; BMP signaling pathway; cellular calcium ion homeostasis; release of sequestered calcium ion into cytosol; calcium ion transport; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2
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Research Articles on RyR-2

1. The cardiac ryanodine receptor gene contains most of the catecholaminergic polymorphic ventricular tachycardia mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RyR-2 antibody

 Reference Product  PubMed Publications
 RYR3 antibody  >5076 publications with RyR-2 and RYR3
 RYR1 antibody  >5075 publications with RyR-2 and RYR1
 ITPR1 antibody  >81 publications with RyR-2 and ITPR1
 SRI antibody  >11 publications with RyR-2 and SRI
 AKAP6 antibody  >5 publications with RyR-2 and AKAP6
 HOMER1 antibody  >4 publications with RyR-2 and HOMER1
 CACNA1C antibody  >4 publications with RyR-2 and CACNA1C
 FKBP1B antibody  >3 publications with RyR-2 and FKBP1B

Pathways associated with anti-RyR-2 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram

Diseases associated with anti-RyR-2 antibody

 Disease Name  Pubmed Publications
 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies  >17421 publications with RyR-2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
 Heart Diseases Antibodies  >849 publications with RyR-2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >485 publications with RyR-2 and Arrhythmias, Cardiac
 Nervous System Diseases Antibodies  >410 publications with RyR-2 and Nervous System Diseases
 Heart Failure Antibodies  >402 publications with RyR-2 and Heart Failure
 Tachycardia Antibodies  >307 publications with RyR-2 and Tachycardia
 Tachycardia, Ventricular Antibodies  >291 publications with RyR-2 and Tachycardia, Ventricular
 Disease Models, Animal Antibodies  >201 publications with RyR-2 and Disease Models, Animal
 Cardiomyopathies Antibodies  >139 publications with RyR-2 and Cardiomyopathies
 Drug Toxicity Antibodies  >104 publications with RyR-2 and Drug Toxicity
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