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SHIP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9519103

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling.… More details

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Product Overview

Online Datasheet in PDF
Product Name
SHIP2, Polyclonal Antibody
Full Product Name
SHIP2 (Phospho-Tyr986/987) Antibody
Product Gene Name
anti-SHIP2 antibody
Product Synonym Names
SHIP2 (Tyr986/987); Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86)(Inositol polyphosphate phosphatase-like protein 1)(INPPL-1)(Protein 51C)(SH2 domain-containing inositol 5'-phosphatase 2)(SH2 domain-containing inositol phosphatase 2)(SHIP-2)
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
This antibody detects endogenous levels of Human SHIP2 (phospho-Tyr986 or 987)
Preparation and Storage
Store at -20 degree C/1 year
Molecular Weight
113,176 Da
OMIM
600829
3D Structure
ModBase 3D Structure for O15357
Immunogen
Synthesized phosho peptide around human SHIP2 (Tyr986 and 987)
Modification
Phospho Specific

Product Categories/Family for anti-SHIP2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-SHIP2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SHIP2 antibody
WB: 1:500-2000
IHC: 1:50-300
ELISA: 2000-20000

Immunohistochemistry (IHC) of anti-SHIP2 antibody

Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4 degree overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
Rabbit Anti-SHIP2 Polyclonal Antibody – Cat# MBS9519103

Other Notes

Small volumes of anti-SHIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHIP2 purchase

MBS9519103 is an antibody targeting SHIP2. Also known as SHIP2 (Phospho-Tyr986/987) Antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SHIP2. It may not necessarily be applicable to this product.

NCBI GI #
269849650
NCBI GeneID
3636
NCBI Accession #
O15357.2
UniProt Primary Accession #
O15357
UniProt Secondary Accession #
Q13577; Q13578; B2RTX5
UniProt Related Accession #
O15357
NCBI Official Full Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
NCBI Official Synonym Full Names
inositol polyphosphate phosphatase-like 1
NCBI Official Symbol
INPPL1
NCBI Official Synonym Symbols
OPSMD; SHIP2
UniProt Protein Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
UniProt Synonym Protein Names
Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
UniProt Gene Name
INPPL1
UniProt Synonym Gene Names
SHIP2; INPPL-1; SH2 domain-containing inositol phosphatase 2; SHIP-2
UniProt Entry Name
SHIP2_HUMAN
NCBI Protein Information
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; SHIP-2; INPPL-1; 51C protein; protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2

UniProt Comments for SHIP2

SHIP-2: an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R.

Protein type: Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid; Motility/polarity/chemotaxis; EC 3.1.3.86

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; cytosol; filopodium

Molecular Function: protein binding; hydrolase activity; SH2 domain binding; actin binding; SH3 domain binding

Biological Process: inositol phosphate metabolic process; immune system process; actin filament organization; glucose metabolic process; endocytosis; response to insulin stimulus; post-embryonic development; negative regulation of cell proliferation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cell adhesion; endochondral ossification

Disease: Opsismodysplasia
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Research Articles on SHIP2

1. SHIP2 play roles in normal development and at in cell proliferation in some cancer derived cells. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHIP2 antibody

 Reference Product  PubMed Publications
 PTEN antibody  >35 publications with SHIP2 and PTEN
 SHC1 antibody  >27 publications with SHIP2 and SHC1
 CBL antibody  >11 publications with SHIP2 and CBL
 MET antibody  >4 publications with SHIP2 and MET
 EPHA2 antibody  >3 publications with SHIP2 and EPHA2
 ITSN1 antibody  >1 publications with SHIP2 and ITSN1

Pathways associated with anti-SHIP2 antibody

 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram

Diseases associated with anti-SHIP2 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >26 publications with SHIP2 and Immune System Diseases
 Inflammation Antibodies  >10 publications with SHIP2 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with SHIP2 and Cardiovascular Diseases
 Skin Diseases Antibodies  >7 publications with SHIP2 and Skin Diseases
 Atherosclerosis Antibodies  >6 publications with SHIP2 and Atherosclerosis
 Liver Diseases Antibodies  >6 publications with SHIP2 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with SHIP2 and Kidney Diseases
 Nervous System Diseases Antibodies  >4 publications with SHIP2 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >4 publications with SHIP2 and Neoplasm Metastasis
 Necrosis Antibodies  >4 publications with SHIP2 and Necrosis

Organs/Tissues associated with anti-SHIP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >136 publications with SHIP2 and Blood
 Bone Antibodies  >51 publications with SHIP2 and Bone
 Bone Marrow Antibodies  >47 publications with SHIP2 and Bone Marrow
 Muscle Antibodies  >27 publications with SHIP2 and Muscle
 Liver Antibodies  >17 publications with SHIP2 and Liver
 Spleen Antibodies  >14 publications with SHIP2 and Spleen
 Kidney Antibodies  >13 publications with SHIP2 and Kidney
 Lung Antibodies  >10 publications with SHIP2 and Lung
 Heart Antibodies  >9 publications with SHIP2 and Heart
 Vascular Antibodies  >9 publications with SHIP2 and Vascular
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