P08247.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Synaptophysin
NCBI Official Synonym Full Names
synaptophysin
NCBI Protein Information
synaptophysin
UniProt Protein Name
Synaptophysin
UniProt Synonym Protein Names
Major synaptic vesicle protein p38
UniProt Entry Name
SYPH_HUMAN
NCBI Summary for SYP
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
UniProt Comments for SYP
SYP: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family.
Protein type: Membrane protein, multi-pass; Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp11.23-p11.22
Cellular Component: cell junction; excitatory synapse; integral to synaptic vesicle membrane; neuron projection; presynaptic active zone; presynaptic membrane; synaptic vesicle; synaptic vesicle membrane; terminal button
Molecular Function: cholesterol binding; identical protein binding; protein self-association; SH2 domain binding; transporter activity
Biological Process: endocytosis; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; synaptic vesicle maturation; synaptic vesicle membrane organization and biogenesis
Disease: Mental Retardation, X-linked 96
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Products associated with anti-SYP antibody
Pathways associated with anti-SYP antibody
Diseases associated with anti-SYP antibody
Organs/Tissues associated with anti-SYP antibody
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