Thyroid Hormone Receptor Alpha (THRA) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; TATA-binding protein binding; thyroid hormone receptor activity; transcription factor activity; transcription factor binding; zinc ion binding

Biological Process: adrenal gland development; brain development; cartilage condensation; cytoplasmic sequestering of transcription factor; embryonic organ development; erythrocyte differentiation; female courtship behavior; gene expression; gut development; hormone-mediated signaling; intracellular receptor-mediated signaling pathway; kidney development; learning and/or memory; liver development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of transcriptional preinitiation complex assembly; ossification; positive regulation of female receptivity; positive regulation of transcription from RNA polymerase II promoter; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptosis; regulation of transcription from RNA polymerase II promoter; response to cold; response to drug; response to nutrient levels; steroid hormone mediated signaling; thyroid gland development; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

Disease: Hypothyroidism, Congenital, Nongoitrous, 6