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TNNI3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601816

Description: Troponin I (TnI) is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle; see also TNNI1 (MIM 191042). The others are troponin T (TnT; see MIM 191041) and troponin C (TnC; see MIM 191040).Function: Troponin I… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNNI3, Polyclonal Antibody
Full Product Name
TNNI3 Antibody
Product Gene Name
anti-TNNI3 antibody
Product Synonym Names
cardiac muscle; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC1; TNNI3; TNNI3_HUMAN; Troponin I; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI; Ttroponin I type 3 (cardiac)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
TNNI3 antibody detects endogenous levels of total TNNI3
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
TNNI3 peptide (MBS9617360) is used for blocking the activity of TNNI3 antibody (MBS9601816)
Molecular Weight
Observed: 26 kDa
Predicted: 25 kDa
3D Structure
ModBase 3D Structure for P19429
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human TNNI3
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Xenopus (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TNNI3 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-TNNI3 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-TNNI3 antibody

Western blot analysis of TNNI3 expression in Jurkat whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-TNNI3 Polyclonal Antibody – Cat# MBS9601816

Immunohistochemistry (IHC) of anti-TNNI3 antibody

MBS9601816 at 1/100 staining Human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-TNNI3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9601816

Other Notes

Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNNI3 purchase

MBS9601816 is an antibody targeting TNNI3. Also known as TNNI3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.

NCBI GI #
151101270
NCBI GeneID
7137
NCBI Accession #
NP_000354.4
UniProt Primary Accession #
P19429
UniProt Related Accession #
P19429
GenBank Nucleotide #
NM_000363.4
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I3, cardiac type
NCBI Official Symbol
TNNI3
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
Protein Family
Troponin
UniProt Gene Name
TNNI3
UniProt Synonym Gene Names
TNNC1
NCBI Protein Information
troponin I, cardiac muscle

NCBI Summary for TNNI3

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
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UniProt Comments for TNNI3

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Research Articles on TNNI3

1. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review].

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNNI3 antibody

 Reference Product  PubMed Publications
 TNNT2 antibody  >48 publications with TNNI3 and TNNT2
 TNNC1 antibody  >11 publications with TNNI3 and TNNC1
 TNNI3K antibody  >5 publications with TNNI3 and TNNI3K
 RCAN3 antibody  >2 publications with TNNI3 and RCAN3
 TNNT1 antibody  >1 publications with TNNI3 and TNNT1
 ACTA1 antibody  >1 publications with TNNI3 and ACTA1

Pathways associated with anti-TNNI3 antibody

 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram

Diseases associated with anti-TNNI3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >66 publications with TNNI3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >65 publications with TNNI3 and Heart Diseases
 Cardiomyopathies Antibodies  >56 publications with TNNI3 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >25 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >18 publications with TNNI3 and Cardiomyopathy, Dilated
 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies  >9 publications with TNNI3 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
 Cardiomyopathy, Restrictive Antibodies  >6 publications with TNNI3 and Cardiomyopathy, Restrictive
 Nervous System Diseases Antibodies  >4 publications with TNNI3 and Nervous System Diseases
 Ventricular Dysfunction, Left Antibodies  >3 publications with TNNI3 and Ventricular Dysfunction, Left
 Hypertension Antibodies  >3 publications with TNNI3 and Hypertension

Organs/Tissues associated with anti-TNNI3 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >52 publications with TNNI3 and Heart
 Embryonic Tissue Antibodies  >2 publications with TNNI3 and Embryonic Tissue
 Lung Antibodies  >2 publications with TNNI3 and Lung
 Uterus Antibodies  >1 publications with TNNI3 and Uterus
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