TOM1L1 Antibody – Rabbit Polyclonal

Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: Golgi stack; lysosome; cytoplasm; endosome membrane; cytosol; endosome

Molecular Function: clathrin binding; protein binding; ubiquitin binding; SH3 domain binding; protein kinase activator activity; protein kinase binding

Biological Process: intracellular protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; negative regulation of mitosis; activation of protein kinase activity; signal transduction; positive regulation of protein amino acid autophosphorylation