Transcription Factor Ec (TFEC) Antibody – Rabbit Polyclonal

TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein dimerization activity; DNA binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent