TRIB3 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; Trbl family

Chromosomal Location of Human Ortholog: 20p13-p12.2

Cellular Component: cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: ATP binding; kinase activity; mitogen-activated protein kinase kinase binding; protein binding; protein kinase binding; protein kinase inhibitor activity; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity

Biological Process: cellular response to insulin stimulus; negative regulation of fat cell differentiation; negative regulation of fatty acid biosynthetic process; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of ubiquitin-protein ligase activity; protein amino acid phosphorylation; regulation of MAP kinase activity; transcription, DNA-dependent