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UCHL5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7605453

MBS7605453 is an antibody targeting UCHL5. Also known as UCHL5 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
UCHL5, Polyclonal Antibody
Full Product Name
UCHL5 Rabbit Polyclonal
Product Gene Name
anti-UCHL5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
37,353 Da
OMIM
610667
Immunogen
Ubiquitin carboxyl-terminal hydrolase L5
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-UCHL5 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-UCHL5 antibody

Immunohistochemistry of paraffin-embedded human colon cancer using MBS7605453 (UCHL5 antibody) at dilution of 1:100
Rabbit Anti-UCHL5 Polyclonal Antibody – Cat# MBS7605453

Western Blot (WB) of anti-UCHL5 antibody

mouse colon tissue were subjected to SDS PAGE followed by western blot with MBS7605453 (UCHL5 Antibody) at dilution of 1:300
Rabbit Anti-UCHL5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS7605453

Other Notes

Small volumes of anti-UCHL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UCHL5. It may not necessarily be applicable to this product.

NCBI GI #
312922364
NCBI GeneID
51377
NCBI Accession #
NP_001186192.1
UniProt Secondary Accession #
Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2
UniProt Related Accession #
Q9Y5K5
GenBank Nucleotide #
NM_001199263.1
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4
NCBI Official Synonym Full Names
ubiquitin C-terminal hydrolase L5
NCBI Official Symbol
UCHL5
NCBI Official Synonym Symbols
UCH37; CGI-70; INO80R; UCH-L5
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase isozyme L5
UniProt Synonym Protein Names
Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
UCHL5
UniProt Synonym Gene Names
UCH37; UCH-L5
UniProt Entry Name
UCHL5_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase isozyme L5

UniProt Comments for UCHL5

UCHL5: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cytosol; nucleus; proteasome complex

Molecular Function: endopeptidase inhibitor activity; protein binding; ubiquitin-specific protease activity

Biological Process: DNA recombination; DNA repair; forebrain morphogenesis; lateral ventricle development; midbrain development; protein deubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
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Research Articles on UCHL5

1. These results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63-linked ubiquitination by UCH37.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-UCHL5 antibody

 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram

Diseases associated with anti-UCHL5 antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >7 publications with UCHL5 and Leukemia
 Cardiovascular Diseases Antibodies  >6 publications with UCHL5 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with UCHL5 and Adenocarcinoma
 Liver Diseases Antibodies  >3 publications with UCHL5 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with UCHL5 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >2 publications with UCHL5 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with UCHL5 and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with UCHL5 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with UCHL5 and Carcinoma, Squamous Cell
 Neoplasm Metastasis Antibodies  >2 publications with UCHL5 and Neoplasm Metastasis

Organs/Tissues associated with anti-UCHL5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with UCHL5 and Liver
 Blood Antibodies  >3 publications with UCHL5 and Blood
 Kidney Antibodies  >2 publications with UCHL5 and Kidney
 Uterus Antibodies  >1 publications with UCHL5 and Uterus
 Lung Antibodies  >1 publications with UCHL5 and Lung
 Skin Antibodies  >1 publications with UCHL5 and Skin
 Bone Antibodies  >1 publications with UCHL5 and Bone
 Spleen Antibodies  >1 publications with UCHL5 and Spleen
 Intestine Antibodies  >1 publications with UCHL5 and Intestine
 Ovary Antibodies  >1 publications with UCHL5 and Ovary
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