Rabbit Anti-UFD1L Polyclonal Antibody – Cat# MBS9127448

Western blot analysis of extracts of various cell lines, using UFD1L antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.

UFD1L Antibody – Rabbit Polyclonal

Name: UFD1L Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9127448
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9127448

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UFD1L, Polyclonal Antibody

Full Product Name

UFD1L Polyclonal Antibody

Product Gene Name

anti-UFD1L antibody

Product Synonym Names

UFD1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

307

OMIM

601754

3D Structure

ModBase 3D Structure for Q92890

Species

Human

Immunogen

Recombinant protein of human UFD1L

Calculated Molecular Weight

34kDa

Product Categories/Family for anti-UFD1L antibody

Polyclonal

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-UFD1L antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Application Notes for anti-UFD1L antibody

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Other Notes

Small volumes of anti-UFD1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UFD1L purchase

MBS9127448 is an antibody targeting UFD1L. Also known as UFD1L Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UFD1L. It may not necessarily be applicable to this product.

NCBI GI #

160332310

NCBI GeneID

7353

NCBI Accession #

Q92890.3

UniProt Primary Accession #

Q92890

UniProt Secondary Accession #

Q9Y5N0; A8MW31

UniProt Related Accession #

Q92890

NCBI Official Full Name

Ubiquitin fusion degradation protein 1 homolog

NCBI Official Synonym Full Names

ubiquitin fusion degradation 1 like (yeast)

NCBI Official Symbol

UFD1L

NCBI Official Synonym Symbols

UFD1

UniProt Protein Name

Ubiquitin fusion degradation protein 1 homolog

UniProt Gene Name

UFD1L

UniProt Synonym Gene Names

UB fusion protein 1

UniProt Entry Name

UFD1_HUMAN

NCBI Protein Information

ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1

UniProt Comments for UFD1L

UFD1L: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Belongs to the UFD1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; ubiquitin-specific protease activity; protein complex binding; receptor binding

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; skeletal development

Research Articles on UFD1L

1. p97-Ufd1-Npl4 is an integral part of G2/M checkpoint signaling and thereby suppresses chromosome instability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UFD1L antibody

Reference Product	PubMed Publications
VCP antibody	>22 publications with UFD1L and VCP
NPLOC4 antibody	>21 publications with UFD1L and NPLOC4
CDC45 antibody	>7 publications with UFD1L and CDC45
FAF1 antibody	>2 publications with UFD1L and FAF1
TBX1 antibody	>1 publications with UFD1L and TBX1
PSMD2 antibody	>1 publications with UFD1L and PSMD2
USP13 antibody	>1 publications with UFD1L and USP13

Pathways associated with anti-UFD1L antibody

Products by Pathway	Pathway Diagram
HRD1/SEL1 ERAD Complex Pathway antibodies	HRD1/SEL1 ERAD Complex Pathway Diagram
HRD1/SEL1 ERAD Complex Pathway antibodies	HRD1/SEL1 ERAD Complex Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
P97-Ufd1-Npl4 Complex Pathway antibodies	P97-Ufd1-Npl4 Complex Pathway Diagram
P97-Ufd1-Npl4 Complex Pathway antibodies	P97-Ufd1-Npl4 Complex Pathway Diagram

Diseases associated with anti-UFD1L antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>28 publications with UFD1L and Congenital Abnormalities
Heart Diseases Antibodies	>24 publications with UFD1L and Heart Diseases
Heart Defects, Congenital Antibodies	>24 publications with UFD1L and Heart Defects, Congenital
Craniofacial Abnormalities Antibodies	>21 publications with UFD1L and Craniofacial Abnormalities
Brain Diseases Antibodies	>4 publications with UFD1L and Brain Diseases
Muscular Diseases Antibodies	>3 publications with UFD1L and Muscular Diseases
Disease Models, Animal Antibodies	>3 publications with UFD1L and Disease Models, Animal
Learning Disorders Antibodies	>2 publications with UFD1L and Learning Disorders
Fibrosis Antibodies	>2 publications with UFD1L and Fibrosis
Cognition Disorders Antibodies	>2 publications with UFD1L and Cognition Disorders

Organs/Tissues associated with anti-UFD1L antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>17 publications with UFD1L and Heart
Bone Antibodies	>6 publications with UFD1L and Bone
Blood Antibodies	>4 publications with UFD1L and Blood
Muscle Antibodies	>3 publications with UFD1L and Muscle
Brain Antibodies	>3 publications with UFD1L and Brain
Thymus Antibodies	>2 publications with UFD1L and Thymus
Embryonic Tissue Antibodies	>2 publications with UFD1L and Embryonic Tissue
Vascular Antibodies	>2 publications with UFD1L and Vascular
Liver Antibodies	>2 publications with UFD1L and Liver
Placenta Antibodies	>1 publications with UFD1L and Placenta