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WDR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5400240

BIOTIN-Conjugated WD repeat-containing protein 5 AntibodyContributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WDR5, Polyclonal Antibody
Full Product Name
WDR5 Antibody BIOTIN-Conjugated
Product Gene Name
anti-WDR5 antibody
Product Synonym Names
2410008O07Rik; AA408785; AA960360; Big; BIG3; BMP2 induced 3 kb gene protein; MGC114572; OTTHUMP00000162494; SWD3 Set1c WD40 repeat protein homolog; WD repeat-containing protein 5; WD repeat-containing protein BIG-3; WDR 5 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.67 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: WDR5 (MBS5400240)
Positive Control: WDR5 (MBS543379)
Antibody/Peptide Pairs
WDR5 peptide (MBS544657) is used for blocking the activity of WDR5 antibody (MBS5400240)
Molecular Weight
36,588 Da
OMIM
609012
3D Structure
ModBase 3D Structure for P61964
Immunogen
Synthetic Peptide taken within amino acid region 150-175 on WDR5 protein.
Molecular Function
Chromatin regulator
Structure
Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular Location
Nucleus
Applications Tested/Suitable for anti-WDR5 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-WDR5 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-WDR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WDR5 purchase

MBS5400240 is an antibody targeting WDR5. Also known as WDR5 Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WDR5. It may not necessarily be applicable to this product.

NCBI Accession #
NP_060058.2
UniProt Primary Accession #
P61964
UniProt Secondary Accession #
Q91VA5; Q9NWX7; Q9UGP9
UniProt Protein Name
WD repeat-containing protein 5
UniProt Synonym Protein Names
BMP2-induced 3-kb gene protein
Protein Family
WD repeat-containing protein
UniProt Gene Name
WDR5
UniProt Synonym Gene Names
BIG3
UniProt Entry Name
WDR5_HUMAN

UniProt Comments for WDR5

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding

Biological Process: histone H3-K4 methylation; neurite development; skeletal development; transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WDR5 antibody

 Reference Product  PubMed Publications
 RBBP5 antibody  >48 publications with WDR5 and RBBP5
 ASH2L antibody  >44 publications with WDR5 and ASH2L
 MLL2 antibody  >16 publications with WDR5 and MLL2
 SETD1A antibody  >16 publications with WDR5 and SETD1A
 MLL4 antibody  >6 publications with WDR5 and MLL4
 HCFC1 antibody  >4 publications with WDR5 and HCFC1
 SETD1B antibody  >3 publications with WDR5 and SETD1B
 CHD8 antibody  >2 publications with WDR5 and CHD8

Diseases associated with anti-WDR5 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with WDR5 and Necrosis
 Fibrosis Antibodies  >4 publications with WDR5 and Fibrosis
 Carcinoma Antibodies  >4 publications with WDR5 and Carcinoma
 Inflammation Antibodies  >3 publications with WDR5 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with WDR5 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with WDR5 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with WDR5 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >2 publications with WDR5 and Heart Diseases
 Hypertrophy Antibodies  >2 publications with WDR5 and Hypertrophy
 Liver Neoplasms Antibodies  >2 publications with WDR5 and Liver Neoplasms

Organs/Tissues associated with anti-WDR5 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >15 publications with WDR5 and Bone
 Blood Antibodies  >8 publications with WDR5 and Blood
 Embryonic Tissue Antibodies  >7 publications with WDR5 and Embryonic Tissue
 Muscle Antibodies  >7 publications with WDR5 and Muscle
 Brain Antibodies  >6 publications with WDR5 and Brain
 Vascular Antibodies  >5 publications with WDR5 and Vascular
 Liver Antibodies  >4 publications with WDR5 and Liver
 Prostate Antibodies  >4 publications with WDR5 and Prostate
 Heart Antibodies  >3 publications with WDR5 and Heart
 Connective Tissue Antibodies  >3 publications with WDR5 and Connective Tissue
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