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WNT3A/WNT3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8535221

The Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes… More details

$430 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WNT3A/WNT3, Polyclonal Antibody
Full Product Name
WNT3A/WNT3
Product Gene Name
anti-WNT3A/WNT3 antibody
Product Synonym Gene Name
WNT3
Product Synonym Names
Proto-oncogene Int-4 homolog, Int 4 antibody, INT4 antibody, MGC131950 antibody, MGC138321 antibody, MGC138323 antibody, Proto-oncogene Int-4 homolog antibody, Proto-oncogene Wnt-3 antibody, wingless type MMTV integration site family member 3 antibody, Wnt 3 proto oncogene protein antibody, WNT 3 proto oncogene protein precursor antibody, wnt3 antibody, WNT3_HUMAN antibody
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; 1 *TBS (pH7.4), 1 %BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Purity/Purification
Immunogen affinity purified
Preparation and Storage
Store at +4 degree C
Molecular Weight
39 kDa
OMIM
165330
3D Structure
ModBase 3D Structure for P56703
Immunogen
Peptide
Conjugate
Non-conjugated
Subcellular location
Secreted
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-WNT3A/WNT3 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-WNT3A/WNT3 antibody
WB: 1:100-1:1,000
IF: 1:50-1:500

Other Notes

Small volumes of anti-WNT3A/WNT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WNT3A/WNT3 purchase

MBS8535221 is an antibody targeting WNT3A/WNT3. Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for WNT3A/WNT3. It may not necessarily be applicable to this product.

NCBI GI #
13540477
NCBI GeneID
7473
NCBI Accession #
NP_110380.1
UniProt Primary Accession #
P56703
UniProt Secondary Accession #
Q2M237; Q9H1J9
UniProt Related Accession #
P56703
GenBank Nucleotide #
NM_030753.4
NCBI Official Full Name
proto-oncogene Wnt-3
NCBI Official Synonym Full Names
Wnt family member 3
NCBI Official Symbol
WNT3
NCBI Official Synonym Symbols
INT4; TETAMS
UniProt Protein Name
Proto-oncogene Wnt-3
UniProt Synonym Protein Names
Proto-oncogene Int-4 homolog
UniProt Gene Name
WNT3
UniProt Synonym Gene Names
INT4
NCBI Protein Information
proto-oncogene Wnt-3

NCBI Summary for WNT3A/WNT3

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
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UniProt Comments for WNT3A/WNT3

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (). Required for normal embryonic development, and especially for limb development (PubMed:14872406).
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Research Articles on WNT3A/WNT3

1. Our data demonstrated an important interdependence between TGF-beta and Wnt/beta-catenin pathways inducing EMT in HER2-overexpressing breast cancer cells. Twist served as a linkage between the two pathways during TGF-beta-induced EMT. A83-01 could inhibit the TGF-beta-initiated pathway interactions and enhance HER2-cells response to trastuzumab treatment
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WNT3A/WNT3 antibody

 Reference Product  PubMed Publications
 LRP6 antibody  >41 publications with WNT3A/WNT3 and LRP6
 BMP4 antibody  >37 publications with WNT3A/WNT3 and BMP4
 FZD1 antibody  >21 publications with WNT3A/WNT3 and FZD1
 FZD7 antibody  >19 publications with WNT3A/WNT3 and FZD7
 FZD4 antibody  >12 publications with WNT3A/WNT3 and FZD4
 SFRP2 antibody  >9 publications with WNT3A/WNT3 and SFRP2
 WLS antibody  >9 publications with WNT3A/WNT3 and WLS
 FZD5 antibody  >9 publications with WNT3A/WNT3 and FZD5
 RYK antibody  >9 publications with WNT3A/WNT3 and RYK
 FZD8 antibody  >6 publications with WNT3A/WNT3 and FZD8

Pathways associated with anti-WNT3A/WNT3 antibody

 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram

Diseases associated with anti-WNT3A/WNT3 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >38 publications with WNT3A/WNT3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >26 publications with WNT3A/WNT3 and Breast Neoplasms
 Nervous System Diseases Antibodies  >26 publications with WNT3A/WNT3 and Nervous System Diseases
 Embryo Loss Antibodies  >23 publications with WNT3A/WNT3 and Embryo Loss
 Adenocarcinoma Antibodies  >20 publications with WNT3A/WNT3 and Adenocarcinoma
 Brain Diseases Antibodies  >16 publications with WNT3A/WNT3 and Brain Diseases
 Neoplasms, Experimental Antibodies  >14 publications with WNT3A/WNT3 and Neoplasms, Experimental
 Necrosis Antibodies  >14 publications with WNT3A/WNT3 and Necrosis
 Fibrosis Antibodies  >11 publications with WNT3A/WNT3 and Fibrosis
 Inflammation Antibodies  >10 publications with WNT3A/WNT3 and Inflammation

Organs/Tissues associated with anti-WNT3A/WNT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >114 publications with WNT3A/WNT3 and Embryonic Tissue
 Brain Antibodies  >97 publications with WNT3A/WNT3 and Brain
 Heart Antibodies  >42 publications with WNT3A/WNT3 and Heart
 Skin Antibodies  >36 publications with WNT3A/WNT3 and Skin
 Kidney Antibodies  >26 publications with WNT3A/WNT3 and Kidney
 Mammary Gland Antibodies  >16 publications with WNT3A/WNT3 and Mammary Gland
 Stomach Antibodies  >7 publications with WNT3A/WNT3 and Stomach
 Testis Antibodies  >6 publications with WNT3A/WNT3 and Testis
 Parathyroid Antibodies  >4 publications with WNT3A/WNT3 and Parathyroid
 Uncharacterized Tissue Antibodies  >2 publications with WNT3A/WNT3 and Uncharacterized Tissue
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