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XRCC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9413535

Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.Ming-Whei Yu, J Natl Cancer Inst, Oct 2003; 95: 1485 - 1488. Nicolas L¨¦vy, Nucleic Acids Res., Jan 2006; 34: 32 - 41.… More details

$260 / 0.05 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
XRCC1, Polyclonal Antibody
Full Product Name
XRCC1 Antibody
Product Gene Name
Product Synonym Names
DNA-repair protein XRCC1; XRC1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total XRCC1 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
69,477 Da
OMIM
194360
3D Structure
ModBase 3D Structure for P18887
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from Internal of human XRCC1.
Target Name
XRCC1

Product Categories/Family for anti-XRCC1 antibody

Applications Tested/Suitable for anti-XRCC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-XRCC1 antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Immunohistochemistry (IHC) of anti-XRCC1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC1 antibody.
Rabbit Anti-XRCC1 Polyclonal Antibody – Cat# MBS9413535

Western Blot (WB) of anti-XRCC1 antibody

Western blot analysis of extracts from Jurkat cells, using XRCC1 antibody.
Rabbit Anti-XRCC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9413535

Western Blot (WB) of anti-XRCC1 antibody

Western blot analysis of extracts from JK cells (Lane 2), HuvEc cells (Lane 3) and COS7 cells (Lane 4), using XRCC1 antiobdy. The lane on the left is treated with systhesized peptide.
Rabbit Anti-XRCC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9413535

Other Notes

Small volumes of anti-XRCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XRCC1 purchase

MBS9413535 is an antibody targeting XRCC1. Also known as XRCC1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XRCC1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA repair protein XRCC1
NCBI Official Synonym Full Names
X-ray repair complementing defective repair in Chinese hamster cells 1
NCBI Official Symbol
XRCC1
NCBI Official Synonym Symbols
RCC
UniProt Protein Name
DNA repair protein XRCC1
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 1
Protein Family
UniProt Gene Name
XRCC1
UniProt Entry Name
XRCC1_HUMAN
NCBI Protein Information
DNA repair protein XRCC1

NCBI Summary for XRCC1

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
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UniProt Comments for XRCC1

XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; enzyme binding; damaged DNA binding

Biological Process: single strand break repair; base-excision repair; DNA repair
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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