Rabbit Anti-ZBTB16 Polyclonal Antibody – Cat# MBS9604125

Western blot analysis of ZBTB16 expression in HL60 (Human promyelocytic leukemia cell line) Whole Cell Lysate, The lane on the left is treated with the antigen-specific peptide.

ZBTB16 Antibody – Rabbit Polyclonal

Name: ZBTB16 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9604125
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9604125

Description: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the… More details

$325 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZBTB16, Polyclonal Antibody

Full Product Name

ZBTB16 Antibody

Product Gene Name

anti-ZBTB16 antibody

Product Synonym Names

AI467657; lu; PLZF; Promyelocytic leukemia zinc finger protein; ZBT16_HUMAN; ZBTB16; Zfp145; Zinc finger and BTB domain containing 16; zinc finger and BTB domain containing protein 16; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145 (Kruppel like expressed in promyelocytic leukemia); Zinc finger protein 145; Zinc finger protein PLZF; Znf145

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Concentration

1mg/ml (lot specific)

Specificity

ZBTB16 antibody detects endogenous levels of total ZBTB16

Antibody/Peptide Pairs

ZBTB16 peptide (MBS9622842) is used for blocking the activity of ZBTB16 antibody (MBS9604125)

Molecular Weight

Observed: 85 kDa
Predicted: 75 kDa

3D Structure

ModBase 3D Structure for Q05516

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Immunogen

A synthesized peptide

Subcellular Location

Nucleus.

Tissue Specificity

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Predicted Cross Reactivity

Pig, Bovine, Rabbit, Dog, Chicken

Similarity

Pig (100%), Bovine (100%), Rabbit (92%), Dog (92%), Chicken (82%)

Conjugation

Unconjugated

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ZBTB16 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ZBTB16 antibody

WB: 1:500-1:2000

Other Notes

Small volumes of anti-ZBTB16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZBTB16 purchase

MBS9604125 is an antibody targeting ZBTB16. Also known as ZBTB16 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZBTB16. It may not necessarily be applicable to this product.

NCBI GI #

66932932

NCBI GeneID

7704

NCBI Accession #

NP_001018011.1

UniProt Primary Accession #

Q05516

UniProt Secondary Accession #

Q8TAL4

UniProt Related Accession #

Q05516

GenBank Nucleotide #

NM_001018011.2

NCBI Official Full Name

zinc finger and BTB domain-containing protein 16 isoform 1

NCBI Official Synonym Full Names

zinc finger and BTB domain containing 16

NCBI Official Symbol

ZBTB16

NCBI Official Synonym Symbols

PLZF; ZNF145

UniProt Protein Name

Zinc finger and BTB domain-containing protein 16

UniProt Synonym Protein Names

Promyelocytic leukemia zinc finger protein; Zinc finger protein 145; Zinc finger protein PLZF

Protein Family

Zinc finger and BTB domain-containing protein

UniProt Gene Name

ZBTB16

UniProt Synonym Gene Names

PLZF; ZNF145

NCBI Protein Information

zinc finger and BTB domain-containing protein 16

NCBI Summary for ZBTB16

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for ZBTB16

Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).

Research Articles on ZBTB16

1. ZBTB16 is a sensitive and specific marker for yolk sac tumour (YST) and is diagnostically superior to AFP and glypican-3 in metastatic and extragonadal settings.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZBTB16 antibody

Reference Product	PubMed Publications
RARA antibody	>32 publications with ZBTB16 and RARA
HDAC1 antibody	>8 publications with ZBTB16 and HDAC1
NCOR2 antibody	>5 publications with ZBTB16 and NCOR2
SUMO1 antibody	>4 publications with ZBTB16 and SUMO1
SIN3A antibody	>4 publications with ZBTB16 and SIN3A
RUNX1T1 antibody	>3 publications with ZBTB16 and RUNX1T1
NCOR1 antibody	>2 publications with ZBTB16 and NCOR1
HDAC4 antibody	>1 publications with ZBTB16 and HDAC4
GATA2 antibody	>1 publications with ZBTB16 and GATA2
BMI1 antibody	>1 publications with ZBTB16 and BMI1

Pathways associated with anti-ZBTB16 antibody

Products by Pathway	Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-ZBTB16 antibody

Disease Name	Pubmed Publications
Leukemia, Promyelocytic, Acute Antibodies	>67 publications with ZBTB16 and Leukemia, Promyelocytic, Acute
Inflammation Antibodies	>12 publications with ZBTB16 and Inflammation
Disease Models, Animal Antibodies	>10 publications with ZBTB16 and Disease Models, Animal
Nervous System Diseases Antibodies	>9 publications with ZBTB16 and Nervous System Diseases
Prostatic Neoplasms Antibodies	>8 publications with ZBTB16 and Prostatic Neoplasms
Cardiovascular Diseases Antibodies	>7 publications with ZBTB16 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>6 publications with ZBTB16 and Neoplasms, Experimental
Necrosis Antibodies	>5 publications with ZBTB16 and Necrosis
Brain Diseases Antibodies	>5 publications with ZBTB16 and Brain Diseases
Lung Diseases Antibodies	>5 publications with ZBTB16 and Lung Diseases

Organs/Tissues associated with anti-ZBTB16 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>108 publications with ZBTB16 and Blood
Testis Antibodies	>41 publications with ZBTB16 and Testis
Embryonic Tissue Antibodies	>20 publications with ZBTB16 and Embryonic Tissue
Brain Antibodies	>14 publications with ZBTB16 and Brain
Muscle Antibodies	>13 publications with ZBTB16 and Muscle
Prostate Antibodies	>11 publications with ZBTB16 and Prostate
Nerve Antibodies	>9 publications with ZBTB16 and Nerve
Eye Antibodies	>8 publications with ZBTB16 and Eye
Connective Tissue Antibodies	>6 publications with ZBTB16 and Connective Tissue
Mouth Antibodies	>6 publications with ZBTB16 and Mouth