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FANCI Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS500071

Fanconi anemia, FA, is a rare disorder where cells cannot prevent, repair, or tolerate DNA damage, leading to cancer, progressive bone marrow failure and developmental abnormalities (Ishiai et al., 2008). 16 genes have been implicated in FA, and their… More details

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Product Overview

Online Datasheet in PDF
Product Name
FANCI, Polyclonal Antibody
Full Product Name
Anti-Phospho-Ser559 FANCI Antibody
Product Gene Name
anti-FANCI antibody
Product Synonym Gene Name
FANCI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Non-Human Primate
Form/Format
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
Purity/Purification
Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Specificity
Specific for endogenous levels of the ~150 kDa FANCI protein phosphorylated at Ser559. Immunolabeling is increased when HeLa cells are treated with 256nm UV light for 20 minutes (A) and completely eliminated by treatment with lambda-Ptase (B).
Preparation and Storage
Storage at -20 degree C is recommended as aliquots may be taken without freeze/thawing due to presence of 50% glycerol.
Stable for at least 1 year at -20 degree C.
Molecular Weight
~150 kDa
OMIM
EF469766 mRNA
3D Structure
ModBase 3D Structure for Q9NVI1
Immunogen Species
Human
Immunogen Information||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser556 conjugated to KLH
Antigen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser559 of human FANCI.
Applications Tested/Suitable for anti-FANCI antibody
Western Blot (WB)
Application Notes for anti-FANCI antibody
WB: 1:250

Western Blot (WB) of anti-FANCI antibody

(B) Western blot of Hela cell lysate treated with UV (~254nm) for 20' showing specific immunolabeling of the ~150 kDa FANCI protein phosphorylated at Ser559 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (lambda-Ptase, 1200 units for 30 min).
Rabbit Anti-FANCI Polyclonal Antibody – Cat# MBS500071

Product References and Citations for anti-FANCI antibody

Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge S, Takata M (2008) FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol Nov;15(11):1138-46.
Walden H, Deans A (2014) The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder. Annu Rev Biophys 2014;43:257-78.
Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gugi SP, Hofmann K, D'Andrea AD, Elledge SJ (2007) Identification of the Fanconi anemia (FANC) I protein, a monoubiquitinated FANCD2 paralog required for crosslink repair. Cell 129(2):289-301.

Other Notes

Small volumes of anti-FANCI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FANCI purchase

MBS500071 is an antibody targeting FANCI. Also known as Anti-Phospho-Ser559 FANCI Antibody. Reactive in Non-Human Primate. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FANCI. It may not necessarily be applicable to this product.

NCBI GI #
164607124
NCBI GeneID
55215
NCBI Accession #
NP_001106849.1
UniProt Primary Accession #
Q9NVI1
UniProt Secondary Accession #
Q96JN1; Q96ST0; Q9BT96; A4ZVE4; A5YMH4; A6NJZ0
UniProt Related Accession #
Q9NVI1
GenBank Nucleotide #
NM_001113378.1
NCBI Official Full Name
Fanconi anemia group I protein isoform 1
NCBI Official Synonym Full Names
Fanconi anemia complementation group I
NCBI Official Symbol
FANCI
NCBI Official Synonym Symbols
KIAA1794
UniProt Protein Name
Fanconi anemia group I protein
Protein Family
Fanconi anemia group I protein
UniProt Gene Name
FANCI
UniProt Synonym Gene Names
KIAA1794; Protein FACI
NCBI Protein Information
Fanconi anemia group I protein

NCBI Summary for FANCI

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for FANCI

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
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Research Articles on FANCI

1. Data suggest that FANCI and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FANCI antibody

 Reference Product  PubMed Publications
 FANCD2 antibody  >129 publications with FANCI and FANCD2
 FANCL antibody  >25 publications with FANCI and FANCL
 FANCM antibody  >22 publications with FANCI and FANCM
 FANCA antibody  >21 publications with FANCI and FANCA
 FANCG antibody  >11 publications with FANCI and FANCG
 UBE2T antibody  >9 publications with FANCI and UBE2T
 FANCE antibody  >9 publications with FANCI and FANCE
 FANCF antibody  >7 publications with FANCI and FANCF
 C19orf40 antibody  >3 publications with FANCI and C19orf40

Pathways associated with anti-FANCI antibody

 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 TP53 Regulates Transcription Of DNA Repair Genes Pathway antibodies  TP53 Regulates Transcription Of DNA Repair Genes Pathway Diagram
 Transcriptional Regulation By TP53 Pathway antibodies  Transcriptional Regulation By TP53 Pathway Diagram

Diseases associated with anti-FANCI antibody

 Disease Name  Pubmed Publications
 Esophageal atresia with or without tracheoesophageal fistula Antibodies  >4380 publications with FANCI and Esophageal atresia with or without tracheoesophageal fistula
 Anemia Antibodies  >149 publications with FANCI and Anemia
 Chromosome Aberrations Antibodies  >15 publications with FANCI and Chromosome Aberrations
 Inflammation Antibodies  >14 publications with FANCI and Inflammation
 Breast Neoplasms Antibodies  >10 publications with FANCI and Breast Neoplasms
 Chromosome Breakage Antibodies  >6 publications with FANCI and Chromosome Breakage
 Liver Diseases Antibodies  >6 publications with FANCI and Liver Diseases
 Cardiovascular Diseases Antibodies  >6 publications with FANCI and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >5 publications with FANCI and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with FANCI and Kidney Diseases

Organs/Tissues associated with anti-FANCI antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >56 publications with FANCI and Bone Marrow
 Bone Antibodies  >56 publications with FANCI and Bone
 Blood Antibodies  >35 publications with FANCI and Blood
 Liver Antibodies  >8 publications with FANCI and Liver
 Heart Antibodies  >7 publications with FANCI and Heart
 Lung Antibodies  >6 publications with FANCI and Lung
 Kidney Antibodies  >6 publications with FANCI and Kidney
 Brain Antibodies  >4 publications with FANCI and Brain
 Intestine Antibodies  >4 publications with FANCI and Intestine
 Stomach Antibodies  >4 publications with FANCI and Stomach
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