ADRB2 Antibody – Polyclonal

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31-q32

Cellular Component: apical plasma membrane; axon; caveola; dendritic spine; early endosome; endosome; integral to plasma membrane; lysosome; nucleus; plasma membrane; receptor complex; sarcolemma

Molecular Function: adenylate cyclase binding; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; G-protein alpha-subunit binding; ionotropic glutamate receptor binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity

Biological Process: adenylate cyclase activation; aging; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; associative learning; bone resorption; brown fat cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; diaphragm contraction; diet induced thermogenesis; endosome to lysosome transport; female pregnancy; G-protein signaling, coupled to cAMP nucleotide second messenger; heat generation; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of apoptosis; positive regulation of ATPase activity; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of potassium ion transport; positive regulation of protein ubiquitination; positive regulation of skeletal muscle growth; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; receptor-mediated endocytosis; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to cold; response to estrogen stimulus; response to progesterone stimulus; response to testosterone stimulus; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase activation (dimerization); wound healing

Disease: Asthma, Susceptibility To; Obesity