Rabbit Anti-DUSP18 Polyclonal Antibody – Cat# MBS9631078

DUSP18 Antibody – Rabbit Polyclonal

Name: DUSP18 Antibody; Polyclonal; Rabbit; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9631078
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9631078

MBS9631078 is an antibody targeting DUSP18. Also known as DUSP18 Antibody. Reactive in Human, Rat. Host: Rabbit. More details

$325 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DUSP18, Polyclonal Antibody

Full Product Name

DUSP18 Antibody

Product Gene Name

anti-DUSP18 antibody

Product Synonym Names

Dual specificity protein phosphatase 18; DUS18_HUMAN; Dusp18; LMW-DSP20; LMWDSP20; Low molecular weight dual specificity phosphatase 20

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human, Rat

Form/Format

Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).

Concentration

1mg/ml (lot specific)

Specificity

DUSP18 Antibody detects endogenous levels of DUSP18.

Preparation and Storage

Store at -20 degree C. Stable for 12 months from date of receipt.

Antibody/Peptide Pairs

DUSP18 peptide (MBS9633461) is used for blocking the activity of DUSP18 antibody (MBS9631078)

Molecular Weight

21,066 Da

OMIM

611446

3D Structure

ModBase 3D Structure for Q8NEJ0

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Immunogen

A synthesized peptide derived from human DUSP18.

Conjugation

Unconjugated

Similarity

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Tissue Specificity

Widely expressed with highest levels in liver, brain, ovary and testis.

Function

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).

Note

Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.

Product Categories/Family for anti-DUSP18 antibody

Cytoplasm; Nucleus; Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side; Primary

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-DUSP18 antibody

ELISA (EIA)(peptide)

Application Notes for anti-DUSP18 antibody

ELISA(peptide): 1:20000-1:40000

Other Notes

Small volumes of anti-DUSP18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP18. It may not necessarily be applicable to this product.

NCBI GI #

51093845

NCBI GeneID

150290

NCBI Accession #

NP_689724.3

UniProt Primary Accession #

Q8NEJ0

UniProt Secondary Accession #

B3KPA4

UniProt Related Accession #

Q8NEJ0

GenBank Nucleotide #

NM_152511.4

NCBI Official Full Name

dual specificity protein phosphatase 18 isoform a

NCBI Official Synonym Full Names

dual specificity phosphatase 18

NCBI Official Symbol

DUSP18

NCBI Official Synonym Symbols

DSP18; DUSP20; LMWDSP20

UniProt Protein Name

Dual specificity protein phosphatase 18

UniProt Synonym Protein Names

Low molecular weight dual specificity phosphatase 20; LMW-DSP20

Protein Family

Dual specificity protein phosphatase

UniProt Gene Name

DUSP18

UniProt Synonym Gene Names

LMWDSP20; LMW-DSP20

UniProt Entry Name

DUS18_HUMAN

NCBI Protein Information

dual specificity protein phosphatase 18; low molecular weight dual specificity phosphatase 20

NCBI Summary for DUSP18

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

UniProt Comments for DUSP18

DUSP18: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Protein type: Mitochondrial; EC 3.1.3.16; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: inactivation of MAPK activity

Research Articles on DUSP18

1. The crystal structure of human DSP18 (official symbol DUSP18) has been determined at 2.0 A resolution.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DUSP18 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>1 publications with DUSP18 and Disease Models, Animal
Liver Diseases Antibodies	>1 publications with DUSP18 and Liver Diseases

Organs/Tissues associated with anti-DUSP18 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with DUSP18 and Testis
Liver Antibodies	>2 publications with DUSP18 and Liver
Brain Antibodies	>2 publications with DUSP18 and Brain
Ovary Antibodies	>1 publications with DUSP18 and Ovary