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IL12RB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9604022

Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IL12RB1, Polyclonal Antibody
Full Product Name
IL12RB1 Antibody
Product Gene Name
anti-IL12RB1 antibody
Product Synonym Names
CD212; cluster of differentiation 212; I12R1_HUMAN; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL12 receptor beta component; IL12RB; Il12rb1; IMD3; IMD30; Interleukin 12 receptor beta 1 chain; Interleukin 12 receptor subunit beta 1; Interleukin-12 receptor subunit beta-1; MGC34454
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
IL12RB1 antibody detects endogenous levels of total IL12RB1
Antibody/Peptide Pairs
IL12RB1 peptide (MBS9622739) is used for blocking the activity of IL12RB1 antibody (MBS9604022)
Molecular Weight
Observed: 73 kDa
Predicted: 74 kDa
3D Structure
ModBase 3D Structure for P42701
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Membrane.
Predicted Cross Reactivity
Bovine
Similarity
Bovine (83%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IL12RB1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IL12RB1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-IL12RB1 antibody

Western blot analysis of IL12RB1 expression in A431 whole cell lysate ;, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-IL12RB1 Polyclonal Antibody – Cat# MBS9604022

Immunohistochemistry (IHC) of anti-IL12RB1 antibody

MBS9604022 at 1/100 staining Human urothelial cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-IL12RB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9604022

Other Notes

Small volumes of anti-IL12RB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL12RB1 purchase

MBS9604022 is an antibody targeting IL12RB1. Also known as IL12RB1 Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL12RB1. It may not necessarily be applicable to this product.

NCBI GI #
586946416
NCBI GeneID
3594
NCBI Accession #
NP_001276952.1
UniProt Primary Accession #
P42701
UniProt Secondary Accession #
Q8N6Q7; A8K308; B2RPF1; B7ZKK3
UniProt Related Accession #
P42701
GenBank Nucleotide #
NM_001290023.1
NCBI Official Full Name
interleukin-12 receptor subunit beta-1 isoform 3
NCBI Official Synonym Full Names
interleukin 12 receptor subunit beta 1
NCBI Official Symbol
IL12RB1
NCBI Official Synonym Symbols
CD212; IMD30; IL12RB; IL-12R-BETA1
UniProt Protein Name
Interleukin-12 receptor subunit beta-1
UniProt Synonym Protein Names
IL-12 receptor beta component; CD_antigen: CD212
Protein Family
Interleukin-12 receptor
UniProt Gene Name
IL12RB1
UniProt Synonym Gene Names
IL12R; IL12RB; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1
NCBI Protein Information
interleukin-12 receptor subunit beta-1

NCBI Summary for IL12RB1

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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UniProt Comments for IL12RB1

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
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Research Articles on IL12RB1

1. A novel IL12RB1 N-terminal signal peptide stop-gain loss-of-function homozygous genotype connects three unrelated Brazilian kindreds with IL-12Rbeta1 deficiency with varying severity and early-onset age mainly regarding susceptibility to Mycobacteria, Histoplasma, and Salmonella infections through the paradoxical diminished cell-surface expression of an impaired IL-12Rbeta1 polypeptide.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL12RB1 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL12RB1 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >46 publications with IL12RB1 and Immune System Diseases
 Inflammation Antibodies  >30 publications with IL12RB1 and Inflammation
 Mycobacterium Infections, Nontuberculous Antibodies  >22 publications with IL12RB1 and Mycobacterium Infections, Nontuberculous
 Lung Diseases Antibodies  >16 publications with IL12RB1 and Lung Diseases
 Necrosis Antibodies  >15 publications with IL12RB1 and Necrosis
 Hypersensitivity Antibodies  >9 publications with IL12RB1 and Hypersensitivity
 Disease Models, Animal Antibodies  >8 publications with IL12RB1 and Disease Models, Animal
 Liver Diseases Antibodies  >4 publications with IL12RB1 and Liver Diseases
 Dermatitis Antibodies  >4 publications with IL12RB1 and Dermatitis
 Carcinoma Antibodies  >4 publications with IL12RB1 and Carcinoma

Organs/Tissues associated with anti-IL12RB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >97 publications with IL12RB1 and Blood
 Lymph Node Antibodies  >18 publications with IL12RB1 and Lymph Node
 Lymph Antibodies  >18 publications with IL12RB1 and Lymph
 Skin Antibodies  >17 publications with IL12RB1 and Skin
 Lung Antibodies  >12 publications with IL12RB1 and Lung
 Spleen Antibodies  >9 publications with IL12RB1 and Spleen
 Liver Antibodies  >6 publications with IL12RB1 and Liver
 Bone Marrow Antibodies  >6 publications with IL12RB1 and Bone Marrow
 Bone Antibodies  >6 publications with IL12RB1 and Bone
 Kidney Antibodies  >3 publications with IL12RB1 and Kidney
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