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RGN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1495255

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro).… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rgn, Polyclonal Antibody
Full Product Name
Rgn Antibody, HRP conjugated
Product Gene Name
anti-Rgn antibody
Product Synonym Names
Regucalcin; RC; Rgn; Smp30; Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat, Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: Rgn (MBS1499334)
HRP Conjugated Antibody: Rgn (MBS1495255)
Molecular Weight
33,390 Da
3D Structure
ModBase 3D Structure for Q03336
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
HRP
Immunogen
Recombinant rat Regucalcin protein
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Rgn antibody
ELISA (EIA)

Other Notes

Small volumes of anti-Rgn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rgn purchase

MBS1495255 is an antibody targeting Rgn. Also known as Rgn Antibody, HRP conjugated. Reactive in Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Rgn. It may not necessarily be applicable to this product.

NCBI GI #
13928740
NCBI GeneID
25106
NCBI Accession #
NP_113734.1
UniProt Primary Accession #
Q03336
UniProt Secondary Accession #
Q63496; Q925W3; Q9QWP2
UniProt Related Accession #
Q03336
GenBank Nucleotide #
NM_031546.1
NCBI Official Full Name
regucalcin
NCBI Official Synonym Full Names
regucalcin (senescence marker protein-30)
NCBI Official Symbol
Rgn
NCBI Official Synonym Symbols
Rc; GNL; Reguc
UniProt Protein Name
Regucalcin
UniProt Synonym Protein Names
Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30
Protein Family
Regucalcin
UniProt Gene Name
Rgn
UniProt Synonym Gene Names
Smp30; RC; GNL; SMP-30
UniProt Entry Name
RGN_RAT
NCBI Protein Information
regucalcin

NCBI Summary for Rgn

binds calcium ions; induces increased activity of the sarcoplasmic reticulum calcium-transporting ATPase [RGD, Feb 2006]

UniProt Comments for Rgn

RGN: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. Belongs to the SMP-30/CGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.17

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: calcium ion binding; enzyme regulator activity; gluconolactonase activity; zinc ion binding

Biological Process: aging; cellular calcium ion homeostasis; kidney development; L-ascorbic acid biosynthetic process; liver development; negative regulation of apoptosis; negative regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of epithelial cell proliferation; negative regulation of nitric oxide biosynthetic process; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; positive regulation of ATPase activity; positive regulation of fatty acid biosynthetic process; positive regulation of GTPase activity; regulation of calcium-mediated signaling; spermatogenesis
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Research Articles on Rgn

1. results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Rgn antibody

 Reference Product  PubMed Publications
 Ebp antibody  >2 publications with Rgn and Ebp
 Bcl2 antibody  >2 publications with Rgn and Bcl2
 Gulo antibody  >2 publications with Rgn and Gulo

Pathways associated with anti-Rgn antibody

 Products by Pathway  Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies  Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram
 Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies  Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Degradation Of Aromatic Compounds Pathway antibodies  Degradation Of Aromatic Compounds Pathway Diagram
 Degradation Of Aromatic Compounds Pathway antibodies  Degradation Of Aromatic Compounds Pathway Diagram
 L-ascorbate Biosynthesis IV Pathway antibodies  L-ascorbate Biosynthesis IV Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-Rgn antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >59 publications with Rgn and Liver Diseases
 Liver Neoplasms Antibodies  >36 publications with Rgn and Liver Neoplasms
 Disease Models, Animal Antibodies  >25 publications with Rgn and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >23 publications with Rgn and Carcinoma, Hepatocellular
 Necrosis Antibodies  >20 publications with Rgn and Necrosis
 Nervous System Diseases Antibodies  >18 publications with Rgn and Nervous System Diseases
 Fibrosis Antibodies  >14 publications with Rgn and Fibrosis
 Neoplasms, Experimental Antibodies  >13 publications with Rgn and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >13 publications with Rgn and Liver Neoplasms, Experimental
 Drug-Induced Liver Injury Antibodies  >11 publications with Rgn and Drug-Induced Liver Injury

Organs/Tissues associated with anti-Rgn antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >192 publications with Rgn and Liver
 Kidney Antibodies  >74 publications with Rgn and Kidney
 Mixed Antibodies  >2 publications with Rgn and Mixed
 Uncharacterized Tissue Antibodies  >1 publications with Rgn and Uncharacterized Tissue
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