• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

STAT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601911

Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAT2, Polyclonal Antibody
Full Product Name
STAT2 Antibody
Product Gene Name
anti-STAT2 antibody
Product Synonym Names
Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF 3; ISGF3; MGC59816; P113; signal transducer and activator of transcription 2 113kD; Signal transducer and activator of transcription 2; STAT113; Stat2; STAT2_HUMAN
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
STAT2 antibody detects endogenous levels of total STAT2
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
STAT2 peptide (MBS9617464) is used for blocking the activity of STAT2 antibody (MBS9601911)
Molecular Weight
Observed: 113 kDa
Predicted: 98 kDa
3D Structure
ModBase 3D Structure for P52630
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human STAT2
Subcellular Location
Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Predicted Cross Reactivity
Pig, Horse, Dog
Similarity
Pig (82%), Horse (82%), Dog (91%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-STAT2 antibody
Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-STAT2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500

Immunofluorescence (IF) of anti-STAT2 antibody

MBS9601911 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-STAT2 Polyclonal Antibody – Cat# MBS9601911

Western Blot (WB) of anti-STAT2 antibody

Western blot analysis of STAT2 expression in IFN treated HeLa whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-STAT2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9601911

Immunohistochemistry (IHC) of anti-STAT2 antibody

MBS9601911 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-STAT2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9601911

Other Notes

Small volumes of anti-STAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT2 purchase

MBS9601911 is an antibody targeting STAT2. Also known as STAT2 Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT2. It may not necessarily be applicable to this product.

NCBI GI #
4885615
NCBI GeneID
6773
NCBI Accession #
NP_005410.1
UniProt Primary Accession #
P52630
UniProt Secondary Accession #
Q16430; Q16431; Q9UDL4; B4DLC7; G3V2M6
UniProt Related Accession #
P52630
GenBank Nucleotide #
NM_005419.3
NCBI Official Full Name
signal transducer and activator of transcription 2 isoform 1
NCBI Official Synonym Full Names
signal transducer and activator of transcription 2
NCBI Official Symbol
STAT2
NCBI Official Synonym Symbols
P113; IMD44; ISGF-3; STAT113
UniProt Protein Name
Signal transducer and activator of transcription 2
UniProt Synonym Protein Names
p113
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
STAT2
NCBI Protein Information
signal transducer and activator of transcription 2

NCBI Summary for STAT2

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Show more

UniProt Comments for STAT2

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Show more

Research Articles on STAT2

1. Priming cells with IFNbeta synergistically enhances IL6 induction in response to treatments that activate NF-kappaB, in a process that depends upon the recruitment of STAT2, IRF9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAT2 antibody

 Reference Product  PubMed Publications
 STAT1 antibody  >564 publications with STAT2 and STAT1
 JAK1 antibody  >145 publications with STAT2 and JAK1
 TYK2 antibody  >117 publications with STAT2 and TYK2
 IRF9 antibody  >111 publications with STAT2 and IRF9
 JAK2 antibody  >70 publications with STAT2 and JAK2
 STAT6 antibody  >53 publications with STAT2 and STAT6
 IFNAR1 antibody  >45 publications with STAT2 and IFNAR1
 IFNAR2 antibody  >25 publications with STAT2 and IFNAR2
 CREBBP antibody  >7 publications with STAT2 and CREBBP
 EP300 antibody  >4 publications with STAT2 and EP300

Pathways associated with anti-STAT2 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram

Diseases associated with anti-STAT2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >121 publications with STAT2 and Neoplasms
 Liver Diseases Antibodies  >43 publications with STAT2 and Liver Diseases
 Inflammation Antibodies  >32 publications with STAT2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >24 publications with STAT2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >23 publications with STAT2 and Liver Neoplasms
 Nervous System Diseases Antibodies  >21 publications with STAT2 and Nervous System Diseases
 Necrosis Antibodies  >19 publications with STAT2 and Necrosis
 Cardiovascular Diseases Antibodies  >17 publications with STAT2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >14 publications with STAT2 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >12 publications with STAT2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-STAT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with STAT2 and Blood
 Liver Antibodies  >48 publications with STAT2 and Liver
 Lung Antibodies  >24 publications with STAT2 and Lung
 Brain Antibodies  >23 publications with STAT2 and Brain
 Bone Antibodies  >22 publications with STAT2 and Bone
 Skin Antibodies  >21 publications with STAT2 and Skin
 Bone Marrow Antibodies  >20 publications with STAT2 and Bone Marrow
 Muscle Antibodies  >20 publications with STAT2 and Muscle
 Kidney Antibodies  >13 publications with STAT2 and Kidney
 Heart Antibodies  >12 publications with STAT2 and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000