Rabbit Anti-IL17F Polyclonal Antibody – Cat# MBS620259

Western blot using Immunochemicals' anti-Human IL17-F antibody shows detection of a band ~15 kDa in size corresponding to recombinant human IL17-F (lane 1). Molecular weight markers are also shown (M). After transfer, the membrane was blocked overnight with 3% BSA in TBS followed by reaction with primary antibody at a 1:1,000 dilution. Detection occurred using DyLightTM649 conjugated anti- Rabbit IgG (p/n 611-143-122) secondary antibody diluted 1:20,000 in blocking buffer (p/n MB-070).

Interleukin 17f (IL17F) Antibody – Rabbit Polyclonal

Name: IL17F Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS620259
Price: 1140 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620259

IL17-F (also known as ML1, ML-1, IL17F, and IL24) is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and… More details

$1140 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 17F (IL17F), Polyclonal Antibody

Full Product Name

Interleukin 17F (IL17-F, ML1, ML-1, IL17F, IL24)

Product Gene Name

anti-IL17F antibody

Product Synonym Names

Anti -Interleukin 17F (IL17-F, ML1, ML-1, IL17F, IL24)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Form/Format

Supplied as a lyophilized powder in PBS, pH 7.2, 0.1% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography. Endotoxin content is estimated to be 10pg/ul (LAL method).

Specificity

Recognizes human.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~15.0kD

Chromosome Location

Chromosome: 6; NC_000006.11 (52101484..52109298, complement). Location: 6p12

OMIM

606496

3D Structure

ModBase 3D Structure for Q96PD4

Immunogen

full length recombinant human IL17-F protein.

Product Categories/Family for anti-IL17F antibody

Antibodies; Abs to Interleukin

Applications Tested/Suitable for anti-IL17F antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-IL17F antibody

Dilution: ELISA:1:20,000-1:100,000
Western Blot:1:500-1:2,000

Other Notes

Small volumes of anti-IL17F antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17F purchase

MBS620259 is an antibody targeting IL17F. Also known as Interleukin 17F (IL17-F, ML1, ML-1, IL17F, IL24). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17F. It may not necessarily be applicable to this product.

NCBI GI #

16418375

NCBI GeneID

112744

NCBI Accession #

NP_443104.1

UniProt Primary Accession #

Q96PD4

UniProt Secondary Accession #

Q6NSI0; Q7Z6P4; Q96PI8; Q9NUE6

UniProt Related Accession #

Q96PD4

GenBank Nucleotide #

NM_052872.3

NCBI Official Full Name

interleukin-17F

NCBI Official Synonym Full Names

interleukin 17F

NCBI Official Symbol

IL17F

NCBI Official Synonym Symbols

ML1; ML-1; CANDF6; IL-17F

UniProt Protein Name

Interleukin-17F

UniProt Synonym Protein Names

Cytokine ML-1; Interleukin-24

Protein Family

Interleukin

UniProt Gene Name

IL17F

UniProt Synonym Gene Names

IL24

UniProt Entry Name

IL17F_HUMAN

NCBI Protein Information

interleukin-17F; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; OTTHUMP00000016602

NCBI Summary for IL17F

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq]

UniProt Comments for IL17F

IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity

Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-8 biosynthetic process; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; cytokine biosynthetic process; cartilage development; regulation of interleukin-2 biosynthetic process; lymphotoxin A biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Disease: Candidiasis, Familial, 6

Research Articles on IL17F

1. After renaturation and purification of IL-17F, the recombinant protein can up-regulate macrophages to secret TNF-alpha, IL-6 and other relative cytokines. It also promoted proliferation of HeLa cells in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL17F antibody

Products by Pathway	Pathway Diagram
IL23-mediated Signaling Events Pathway antibodies	IL23-mediated Signaling Events Pathway Diagram

Diseases associated with anti-IL17F antibody

Disease Name	Pubmed Publications
Hyperplasia Antibodies	>2 publications with IL17F and Hyperplasia
Carcinoma, Hepatocellular Antibodies	>1 publications with IL17F and Carcinoma, Hepatocellular
Drug-Induced Liver Injury Antibodies	>1 publications with IL17F and Drug-Induced Liver Injury
Esophageal Neoplasms Antibodies	>1 publications with IL17F and Esophageal Neoplasms
Liver Neoplasms, Experimental Antibodies	>1 publications with IL17F and Liver Neoplasms, Experimental
Hepatitis Antibodies	>1 publications with IL17F and Hepatitis

Organs/Tissues associated with anti-IL17F antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>37 publications with IL17F and Blood
Mixed Antibodies	>2 publications with IL17F and Mixed