Rabbit Anti-KRT2 Polyclonal Antibody – Cat# MBS9507840

Western blot analysis of lysate from HeLa cells, using Keratin-pan (Acetyl-Lys194) Antibody.

Keratin-Pan (KRT2) Antibody – Rabbit Polyclonal

Name: KRT2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9507840
Price: 300 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9507840

MBS9507840 is an antibody targeting KRT2. Also known as Keratin-pan (Acetyl-Lys194) Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$300 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Keratin-pan (KRT2), Polyclonal Antibody

Full Product Name

Keratin-pan (Acetyl-Lys194) Antibody

Product Gene Name

anti-KRT2 antibody

Product Synonym Gene Name

KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84

Product Synonym Names

KRT2; KRT2A; KRT2E; Keratin; type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2; KRT76; KRT2B; KRT2P; Keratin; type II cytoskeletal 2 oral; Cytokeratin-2P; CK-2P; K2P; Keratin-76; K76; Type-II keratin Kb9; KRT3; Keratin; type II cytoskeletal 3; 65 kDa cytokeratin; Cytokeratin-3; CK-3; Keratin-3; K3; Type-II keratin Kb3; KRT5; Keratin; type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5; KRT6A; K6A; KRT6D; Keratin; type II cytoskeletal 6A; Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; allergen Hom s 5; KRT6B; K6B; KRTL1; Keratin; type II cytoskeletal 6B; Cytokeratin-6B; CK-6B; Keratin-6B; K6B; Type-II keratin Kb10; KRT6C; KRT6E; Keratin; type II cytoskeletal 6C; Cytokeratin-6C; CK-6C; Cytokeratin-6E; CK-6E; Keratin K6h; Keratin-6C; K6C; Type-II keratin Kb12; KRT71; K6IRS1; KB34; KRT6IRS1; Keratin; type II cytoskeletal 71; Cytokeratin-71; CK-71; Keratin-71; K71; Type II inner root sheath-specific keratin-K6irs1; Keratin 6 irs; hK6irs; hK6irs1; Type-II keratin Kb34; KRT72; K6IRS2; KB35; KRT6; KRT6IRS2; Keratin; type II cytoskeletal 72; Cytokeratin-72; CK-72; Keratin-72; K72; Type II inner root sheath-specific keratin-K6irs2; Type-II keratin Kb35; KRT73; K6IRS3; KB36; KRT6IRS3; Keratin; type II cytoskeletal 73; Cytokeratin-73; CK-73; Keratin-73; K73; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36; KRT74; K6IRS4; KB37; KRT5C; KRT6IRS4; Keratin; type II cytoskeletal 74; Cytokeratin-74; CK-74; Keratin-5c; K5C; Keratin-74; K74; Type II inner root sheath-specific keratin-K6irs4; Type-II keratin Kb37; KRT75; K6HF; KB18; Keratin; type II cytoskeletal 75; Cytokeratin-75; CK-75; Keratin-6 hair follicle; hK6hf; Keratin-75; K75; Type II keratin-K6hf; Type-II keratin Kb18; KRT79; K6L; KB38; KRT6L; Keratin; type II cytoskeletal 79; Cytokeratin-79; CK-79; Keratin-6-like; Keratin-6L; Keratin-79; K79; Type-II keratin Kb38

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-purified from rabbit antiserum by affinity-chromatography using acetylated peptide. The antibody against non-acetylated peptide was removed by chromatography using corresponding non-acetylated peptide.

Concentration

1 mg/ml (lot specific)

Specificity

Keratin-pan (Acetyl-Lys194) Antibody detects endogenous levels of Keratin-pan protein only when acetylated at Lys194.

Preparation and Storage

Stable at -20 degree C for at least 1 year.

Molecular Weight

65 kDa

OMIM

M99061 mRNA

3D Structure

ModBase 3D Structure for P35908

Target Modification

Acetyl

Modification Sites

H:K194; M:K172; R:K174

Immunogen

The antiserum was produced against synthesized Acetyl-peptide derived from human Keratin-pan around the Acetylation site of Lys194.

Immunogen Range

151-200

Applications Tested/Suitable for anti-KRT2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-KRT2 antibody

WB: 1:500~1:1000
ELISA: 1:10000

Other Notes

Small volumes of anti-KRT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT2. It may not necessarily be applicable to this product.

NCBI GI #

47132620

NCBI GeneID

3849

NCBI Accession #

NP_000414.2

UniProt Primary Accession #

P35908

UniProt Secondary Accession #

Q4VAQ2

UniProt Related Accession #

P35908

GenBank Nucleotide #

NM_000423.2

NCBI Official Full Name

keratin, type II cytoskeletal 2 epidermal

NCBI Official Synonym Full Names

keratin 2

NCBI Official Symbol

KRT2

NCBI Official Synonym Symbols

K2e; KRTE; CK-2e; KRT2A; KRT2E

UniProt Protein Name

Keratin, type II cytoskeletal 2 epidermal

UniProt Synonym Protein Names

Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2

Protein Family

Keratin

UniProt Gene Name

KRT2

UniProt Synonym Gene Names

KRT2A; KRT2E; CK-2e; K2e

NCBI Protein Information

keratin, type II cytoskeletal 2 epidermal

NCBI Summary for KRT2

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

UniProt Comments for KRT2

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization.

Research Articles on KRT2

1. Report genetic/clinical spectrum of KRT2 mutations in keratinopathic ichthyosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-KRT2 antibody

Disease Name	Pubmed Publications
Ichthyosis Bullosa of Siemens Antibodies	>13 publications with KRT2 and Ichthyosis Bullosa of Siemens
Liver Diseases Antibodies	>5 publications with KRT2 and Liver Diseases
Hyperplasia Antibodies	>3 publications with KRT2 and Hyperplasia
Drug-Related Side Effects and Adverse Reactions Antibodies	>2 publications with KRT2 and Drug-Related Side Effects and Adverse Reactions
Inflammation Antibodies	>2 publications with KRT2 and Inflammation
Liver Neoplasms Antibodies	>2 publications with KRT2 and Liver Neoplasms
Necrosis Antibodies	>2 publications with KRT2 and Necrosis
Poisoning Antibodies	>2 publications with KRT2 and Poisoning
Kidney Diseases Antibodies	>2 publications with KRT2 and Kidney Diseases
Drug-Induced Liver Injury Antibodies	>2 publications with KRT2 and Drug-Induced Liver Injury

Organs/Tissues associated with anti-KRT2 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>29 publications with KRT2 and Skin
Blood Antibodies	>7 publications with KRT2 and Blood