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Matrix Gla Protein (MGLAP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS968866

MBS968866 is an antibody targeting MGLAP. Also known as Rabbit anti-human Matrix Gla protein polyclonal Antibody. Reactive in Human. Host: Rabbit. More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Matrix Gla protein (MGLAP), Polyclonal Antibody
Full Product Name
Rabbit anti-human Matrix Gla protein polyclonal Antibody
Product Gene Name
anti-MGLAP antibody
Product Synonym Names
MGP; Cell growth-inhibiting gene 36 protein; MGP; GIG36
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: MGLAP (MBS968866)
Biotin Conjugated Antibody: MGLAP (MBS1494006)
Matching Pairs
Unconjugated Antibody: MGLAP (MBS968866)
FITC Conjugated Antibody: MGLAP (MBS1498092)
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OMIM
154870
3D Structure
ModBase 3D Structure for P08493
Immunogen Species
Homo sapiens (Human)
Research Area
Signal Transduction
Target Names
MGP
Immunogen
Recombinant human Matrix Gla protein protein(20-96aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32821 / sc-32820 / sc-66965
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MGLAP antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-MGLAP antibody
IHC: 1:200-1:500

Immunohistochemistry (IHC) of anti-MGLAP antibody

IHC image of MBS968866 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica Bond system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Rabbit Anti-MGLAP Polyclonal Antibody – Cat# MBS968866

Immunohistochemistry (IHC) of anti-MGLAP antibody

IHC image of MBS968866 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica Bond system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Rabbit Anti-MGLAP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS968866

Other Notes

Small volumes of anti-MGLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MGLAP. It may not necessarily be applicable to this product.

NCBI GI #
49574514
NCBI GeneID
4256
NCBI Accession #
NP_000891.2
UniProt Primary Accession #
P08493
UniProt Secondary Accession #
Q2TU41; Q567P9; Q6ICN5; A0M8W5; B2R519; J3KMX7
UniProt Related Accession #
P08493
GenBank Nucleotide #
NM_000900.3
NCBI Official Full Name
matrix Gla protein isoform 2
NCBI Official Synonym Full Names
matrix Gla protein
NCBI Official Symbol
MGP
NCBI Official Synonym Symbols
NTI; GIG36; MGLAP
UniProt Protein Name
Matrix Gla protein
UniProt Synonym Protein Names
Cell growth-inhibiting gene 36 protein
Protein Family
Matrix Gla protein
UniProt Gene Name
MGP
UniProt Synonym Gene Names
MGLAP; MGP
UniProt Entry Name
MGP_HUMAN
NCBI Protein Information
matrix Gla protein

NCBI Summary for MGLAP

The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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UniProt Comments for MGLAP

MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; extracellular matrix structural constituent; protein binding; structural constituent of bone

Biological Process: cartilage condensation; cell differentiation; ossification; regulation of bone mineralization

Disease: Keutel Syndrome
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Research Articles on MGLAP

1. MGP expression is significantly lower in diseased relative to normal aortic valve interstitial cells. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MGLAP antibody

 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram

Diseases associated with anti-MGLAP antibody

 Disease Name  Pubmed Publications
 Vascular Calcification Antibodies  >205 publications with MGLAP and Vascular Calcification
 Cardiovascular Diseases Antibodies  >175 publications with MGLAP and Cardiovascular Diseases
 Heart Diseases Antibodies  >79 publications with MGLAP and Heart Diseases
 Kidney Diseases Antibodies  >77 publications with MGLAP and Kidney Diseases
 Atherosclerosis Antibodies  >55 publications with MGLAP and Atherosclerosis
 Disease Models, Animal Antibodies  >42 publications with MGLAP and Disease Models, Animal
 Inflammation Antibodies  >34 publications with MGLAP and Inflammation
 Hypertension Antibodies  >25 publications with MGLAP and Hypertension
 Carcinoma Antibodies  >22 publications with MGLAP and Carcinoma
 Necrosis Antibodies  >20 publications with MGLAP and Necrosis

Organs/Tissues associated with anti-MGLAP antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >277 publications with MGLAP and Bone
 Vascular Antibodies  >268 publications with MGLAP and Vascular
 Blood Antibodies  >211 publications with MGLAP and Blood
 Muscle Antibodies  >130 publications with MGLAP and Muscle
 Kidney Antibodies  >121 publications with MGLAP and Kidney
 Connective Tissue Antibodies  >93 publications with MGLAP and Connective Tissue
 Heart Antibodies  >80 publications with MGLAP and Heart
 Brain Antibodies  >50 publications with MGLAP and Brain
 Lung Antibodies  >44 publications with MGLAP and Lung
 Liver Antibodies  >43 publications with MGLAP and Liver
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