ACVR1C Antibody – Rabbit Polyclonal

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Cellular Component: activin receptor complex; cell surface; cytoplasm; integral to membrane; membrane; plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transferase activity; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; apoptosis; apoptotic nuclear changes; cell differentiation; determination of left/right symmetry; in utero embryonic development; negative regulation of insulin secretion; phosphorylation; positive regulation of apoptosis; positive regulation of caspase activity; protein amino acid phosphorylation; regulation of apoptosis; response to dietary excess; response to glucose stimulus; response to insulin stimulus; sequestering of lipid; transforming growth factor beta receptor complex assembly; transmembrane receptor protein serine/threonine kinase signaling pathway; trophectodermal cell proliferation