Rabbit Anti-CBX8 Polyclonal Antibody – Cat# MBS6281254

CBX8 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).

CBX8 Antibody – Rabbit Polyclonal

Name: CBX8 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6281254
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6281254

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CBX8, Polyclonal Antibody

Full Product Name

CBX8, ID (CBX8, PC3, RC1, Chromobox protein homolog 8, Polycomb 3 homolog, Rectachrome 1) (PE)

Product Gene Name

anti-CBX8 antibody

Product Synonym Names

CBX8; PC3; RC1; Chromobox protein homolog 8; Polycomb 3 homolog; Rectachrome 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

43,396 Da

3D Structure

ModBase 3D Structure for Q9HC52

Immunogen

CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human CBX8.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-CBX8 antibody

Antibodies; Chromatin Proteins

Applications Tested/Suitable for anti-CBX8 antibody

Western Blot (WB), FLISA

Application Notes for anti-CBX8 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CBX8 antibody

Dietrich, N., et al. EMBO J. 26(6):1637-1648(2007). Olsen, J.V., et al. Cell 127(3):635-648(2006). Stelzl, U., et al. Cell 122(6):957-968(2005). Obuse, C., et al. Genes Cells 9(2):105-120(2004). Levine, S.S., et al. Mol. Cell. Biol. 22(17):6070-6078(2002).

Other Notes

Small volumes of anti-CBX8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBX8 purchase

MBS6281254 is an antibody targeting CBX8. Also known as CBX8, ID (CBX8, PC3, RC1, Chromobox protein homolog 8, Polycomb 3 homolog, Rectachrome 1) (PE). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CBX8. It may not necessarily be applicable to this product.

NCBI GI #

10190682

NCBI GeneID

57332

NCBI Accession #

NP_065700.1

UniProt Primary Accession #

Q9HC52

UniProt Secondary Accession #

Q96H39; Q9NR07

UniProt Related Accession #

Q9HC52

GenBank Nucleotide #

NM_020649.2

NCBI Official Full Name

chromobox protein homolog 8

NCBI Official Synonym Full Names

chromobox 8

NCBI Official Symbol

CBX8

NCBI Official Synonym Symbols

PC3; RC1

UniProt Protein Name

Chromobox protein homolog 8

UniProt Synonym Protein Names

Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1

Protein Family

Chromobox protein

UniProt Gene Name

CBX8

UniProt Synonym Gene Names

PC3; RC1; Pc3; hPc3

UniProt Entry Name

CBX8_HUMAN

NCBI Protein Information

chromobox protein homolog 8

UniProt Comments for CBX8

CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; heterochromatin; nuclear chromatin; PcG protein complex; nucleus

Molecular Function: protein binding; single-stranded RNA binding; ubiquitin-protein ligase activity; methylated histone residue binding

Biological Process: transcription, DNA-dependent; histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter

Research Articles on CBX8

1. Low CBX8 expression was associated with distant metastasis in colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBX8 antibody

Reference Product	PubMed Publications
BMI1 antibody	>6 publications with CBX8 and BMI1
EZH2 antibody	>5 publications with CBX8 and EZH2
MLLT3 antibody	>2 publications with CBX8 and MLLT3
PHC2 antibody	>2 publications with CBX8 and PHC2
RNF2 antibody	>2 publications with CBX8 and RNF2
SUZ12 antibody	>1 publications with CBX8 and SUZ12
PCGF2 antibody	>1 publications with CBX8 and PCGF2

Pathways associated with anti-CBX8 antibody

Products by Pathway	Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Oxidative Stress Induced Senescence Pathway antibodies	Oxidative Stress Induced Senescence Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies	SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram
SUMOylation Of DNA Damage Response And Repair Proteins Pathway antibodies	SUMOylation Of DNA Damage Response And Repair Proteins Pathway Diagram
SUMOylation Of RNA Binding Proteins Pathway antibodies	SUMOylation Of RNA Binding Proteins Pathway Diagram

Diseases associated with anti-CBX8 antibody

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>2 publications with CBX8 and Cell Transformation, Neoplastic
Memory Disorders Antibodies	>1 publications with CBX8 and Memory Disorders
Brain Diseases Antibodies	>1 publications with CBX8 and Brain Diseases
Liver Neoplasms Antibodies	>1 publications with CBX8 and Liver Neoplasms
Death Antibodies	>1 publications with CBX8 and Death
Disease Models, Animal Antibodies	>1 publications with CBX8 and Disease Models, Animal
Liver Diseases Antibodies	>1 publications with CBX8 and Liver Diseases

Organs/Tissues associated with anti-CBX8 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2 publications with CBX8 and Bone
Brain Antibodies	>2 publications with CBX8 and Brain
Lung Antibodies	>2 publications with CBX8 and Lung
Prostate Antibodies	>1 publications with CBX8 and Prostate
Bone Marrow Antibodies	>1 publications with CBX8 and Bone Marrow