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CD226 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9130793
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This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CD226, Polyclonal Antibody
Full Product Name
CD226 Polyclonal Antibody
Product Gene Name
anti-CD226 antibody
Product Synonym Names
DNAM-1; DNAM1; PTA1; TLiSA1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
39kDa
OMIM
U56102 mRNA
3D Structure
ModBase 3D Structure for Q15762
Immunogen
Recombinant protein of human CD226
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-CD226 antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD226 antibody
Western Blot (WB)
Application Notes for anti-CD226 antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-CD226 antibody

Western blot analysis of extracts of mouse lung, using CD226 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
Rabbit Anti-CD226 Polyclonal Antibody – Cat# MBS9130793

Other Notes

Small volumes of anti-CD226 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD226 purchase

MBS9130793 is an antibody targeting CD226. Also known as CD226 Polyclonal Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD226. It may not necessarily be applicable to this product.

NCBI GI #
317373338
NCBI GeneID
10666
NCBI Accession #
Q15762.2
UniProt Primary Accession #
Q15762
UniProt Secondary Accession #
B2R818
UniProt Related Accession #
Q15762
NCBI Official Full Name
CD226 antigen
NCBI Official Synonym Full Names
CD226 molecule
NCBI Official Symbol
CD226
NCBI Official Synonym Symbols
PTA1; DNAM1; DNAM-1; TLiSA1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1; DNAM-1; CD_antigen: CD226
Protein Family
CD226 antigen
UniProt Gene Name
CD226
UniProt Synonym Gene Names
DNAM1; DNAM-1
NCBI Protein Information
CD226 antigen

UniProt Comments for CD226

DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.2

Cellular Component: cell surface; cell-cell adherens junction; integral to plasma membrane; lipid raft; plasma membrane

Molecular Function: cell adhesion molecule binding; integrin binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity

Biological Process: cell adhesion; cell recognition; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; signal transduction
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Research Articles on CD226

1. our results support and explain the mechanism behind the recently reported finding that in EOC, NK-cell recognition and killing of tumor cells was mainly dependent on DNAM-1 signaling while the contribution of the NKG2D receptor-ligand pathway was complementary and uncertain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD226 antibody

 Reference Product  PubMed Publications
 KLRK1 antibody  >21 publications with CD226 and KLRK1
 NCR1 antibody  >10 publications with CD226 and NCR1
 NCR3 antibody  >6 publications with CD226 and NCR3
 FYN antibody  >5 publications with CD226 and FYN
 ITGAL antibody  >3 publications with CD226 and ITGAL
 ITGB2 antibody  >2 publications with CD226 and ITGB2

Pathways associated with anti-CD226 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CD226 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >52 publications with CD226 and Immune System Diseases
 Neoplasms Antibodies  >49 publications with CD226 and Neoplasms
 Nervous System Diseases Antibodies  >12 publications with CD226 and Nervous System Diseases
 Inflammation Antibodies  >11 publications with CD226 and Inflammation
 Necrosis Antibodies  >11 publications with CD226 and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with CD226 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with CD226 and Diabetes Mellitus, Type 1
 Respiratory Tract Diseases Antibodies  >8 publications with CD226 and Respiratory Tract Diseases
 Colorectal Neoplasms Antibodies  >7 publications with CD226 and Colorectal Neoplasms
 Bone Diseases Antibodies  >4 publications with CD226 and Bone Diseases

Organs/Tissues associated with anti-CD226 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with CD226 and Blood
 Vascular Antibodies  >8 publications with CD226 and Vascular
 Lung Antibodies  >7 publications with CD226 and Lung
 Lymph Node Antibodies  >6 publications with CD226 and Lymph Node
 Liver Antibodies  >6 publications with CD226 and Liver
 Spleen Antibodies  >5 publications with CD226 and Spleen
 Thymus Antibodies  >3 publications with CD226 and Thymus
 Mixed Antibodies  >3 publications with CD226 and Mixed
 Uterus Antibodies  >2 publications with CD226 and Uterus
 Kidney Antibodies  >1 publications with CD226 and Kidney
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