CDK2 Antibody – Rabbit Polyclonal

CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276

Protein type: Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Kinase, protein; EC 2.7.11.22; Protein kinase, CMGC; CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily

Cellular Component: Y chromosome; Cajal body; transcription factor complex; chromosome, telomeric region; cytoskeleton; intracellular membrane-bound organelle; X chromosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; condensed chromosome; cytosol; nucleus; endosome

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein complex binding; histone kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: mitosis; response to cAMP; regulation of cell cycle; histone phosphorylation; positive regulation of transcription, DNA-dependent; DNA repair; cell cycle; protein amino acid phosphorylation; peptidyl-serine phosphorylation; cellular response to insulin stimulus; meiotic cell cycle; cell division; positive regulation of cell proliferation; response to electrical stimulus; response to DNA damage stimulus; phosphorylation; potassium ion transport; positive regulation of DNA replication initiation; G1/S transition of mitotic cell cycle