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CDNF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8111752

Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDNF, Polyclonal Antibody
Full Product Name
Anti-CDNF Antibody, Rabbit Polyclonal
Product Gene Name
anti-CDNF antibody
Product Synonym Names
CDNF/ARMETL1 Antibody, Rabbit PAb; cerebral dopamine neurotrophic factor; Anti-9330140G23 Antibody; Anti-Armetl1 Antibody
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Liquid; 0.2um filtered solution in PBS
Purity/Purification
Protein A
Specificity
Mouse CDNF/ARMETL1
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Molecular Weight
21,032 Da
3D Structure
ModBase 3D Structure for Q8CC36
Immunogen
Recombinant Mouse CDNF protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CDNF (rM CDNF). Total IgG was purified by Protein A affinity chromatography .
Applications Tested/Suitable for anti-CDNF antibody
ELISA (EIA)
Application Notes for anti-CDNF antibody
ELISA: 1:1000-1:2000

Product References and Citations for anti-CDNF antibody

Choi JM, et al. (2011) Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. Neurosci Lett. 493(3): 97-101.Sun ZP, et al. (2011) Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells. J Neurochem. 117(1): 121-32.Lohoff FW, et al. (2009) Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. Neurosci Lett. 453(3): 199-203.Lindholm P, et al. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. 448(7149): 73-7.

Other Notes

Small volumes of anti-CDNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDNF purchase

MBS8111752 is an antibody targeting CDNF. Also known as Anti-CDNF Antibody, Rabbit Polyclonal. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDNF. It may not necessarily be applicable to this product.

NCBI GI #
29244056
NCBI GeneID
227526
NCBI Accession #
NP_808315.1
UniProt Primary Accession #
Q8CC36
UniProt Related Accession #
Q8CC36
GenBank Nucleotide #
NM_177647.4
NCBI Official Full Name
cerebral dopamine neurotrophic factor
NCBI Official Synonym Full Names
cerebral dopamine neurotrophic factor
NCBI Official Symbol
Cdnf
NCBI Official Synonym Symbols
Armetl1; 9330140G23
UniProt Protein Name
Cerebral dopamine neurotrophic factor
UniProt Synonym Protein Names
ARMET-like protein 1; Conserved dopamine neurotrophic factor
Protein Family
Cerebral dopamine neurotrophic factor
UniProt Gene Name
Cdnf
UniProt Synonym Gene Names
Armetl1
UniProt Entry Name
CDNF_MOUSE
NCBI Protein Information
cerebral dopamine neurotrophic factor; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; conserved dopamine neurotrophic factor

UniProt Comments for CDNF

ARMETL1: Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Belongs to the ARMET family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular region

Molecular Function: growth factor activity
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Research Articles on CDNF

1. CDNF (Armetl1) is expressed in several tissues, including the mouse embryonic and postnatal brain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDNF antibody

 Disease Name  Pubmed Publications
 Movement Disorders Antibodies  >12 publications with CDNF and Movement Disorders
 Disease Models, Animal Antibodies  >11 publications with CDNF and Disease Models, Animal
 Bone Marrow Diseases Antibodies  >1 publications with CDNF and Bone Marrow Diseases
 Embryo Loss Antibodies  >1 publications with CDNF and Embryo Loss

Organs/Tissues associated with anti-CDNF antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with CDNF and Brain
 Muscle Antibodies  >2 publications with CDNF and Muscle
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