Connective Tissue Growth Factor (CTGF) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: extracellular region; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane

Molecular Function: heparin binding; integrin binding; protein binding; protein C-terminus binding

Biological Process: cell adhesion; cell-cell signaling; epidermis development; positive regulation of cell differentiation; positive regulation of JNK cascade; positive regulation of stress fiber formation; response to wounding; transcription initiation from RNA polymerase II promoter