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CYP2C23 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621960

Cytochrome P450 2C23 (CYP2C23) is one member of the CP450 subfamily. CYP2C23 have been studied with respect to the metabolism of clinically important drugs and endogenous chemicals, such as arachidonic acid (AA). CP450 enzymes are expressed throughout the… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Cyp2c23, Polyclonal Antibody
Full Product Name
anti-Mouse Cyp2c23 (cytochrome P450, family 2, subfamily c, polypeptide 23, (Arachidonic acid epoxygenase, Cyp2c-23, CYPIIC23, Cytochrome P450 2C23)
Product Gene Name
anti-Cyp2c23 antibody
Product Synonym Names
Anti -Cyp2c23 (cytochrome P450, family 2, subfamily c, polypeptide 23, (Arachidonic acid epoxygenase, Cyp2c-23, CYPIIC23, Cytochrome P450 2C23)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 30% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Concentration
0.5mg/ml (lot specific)
Specificity
Recognizes mouse cytochrome P450 2C23.
Preparation and Storage
May be store at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,433 Da
Chromosome Location
Chromosome: 1; NC_005100.2 (249204049..249228689). Location: 1q54
3D Structure
ModBase 3D Structure for P24470
Immunogen
KLH conjugated synthetic peptide IGRHQPPSMKDKMK

Product Categories/Family for anti-Cyp2c23 antibody

Antibodies; Abs to Enzymes; Cytochrome
Applications Tested/Suitable for anti-Cyp2c23 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Cyp2c23 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.05-0.2ug/ml
Western Blot: 0.5-1.0ug/ml

Testing Data of anti-Cyp2c23 antibody

Lane 1: Smart Protein Standard (Middle-Range) Lane 2: 50ug Mouse liver tissue lysate Primary antibody: 1 ug/ml MBS621960 Secondary antibody: Goat Anti-Rabbit IgG (H&L) [HRP] Polyclonal Antibody
Rabbit Anti-CYP2C23 Polyclonal Antibody – Cat# MBS621960

Testing Data of anti-Cyp2c23 antibody

Lane 1: Smart Protein Standard (Middle-Range) Lane 2: 50ug Mouse liver tissue lysate Primary antibody: 0.5ug/ml MBS621960 The result was developed with One-Step WesternTM Complete Kit (Rabbit)
Rabbit Anti-CYP2C23 Polyclonal Antibody, Testing Data – Cat# MBS621960

Other Notes

Small volumes of anti-Cyp2c23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cyp2c23 purchase

MBS621960 is an antibody targeting Cyp2c23. Also known as anti-Mouse Cyp2c23 (cytochrome P450, family 2, subfamily c, polypeptide 23, (Arachidonic acid epoxygenase, Cyp2c-23, CYPIIC23, Cytochrome P450 2C23). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cyp2c23. It may not necessarily be applicable to this product.

NCBI GI #
140969796
NCBI GeneID
83790
NCBI Accession #
NP_114027.2
UniProt Primary Accession #
P24470
UniProt Secondary Accession #
Q63914; Q64534
UniProt Related Accession #
P24470; Q68G40
GenBank Nucleotide #
NM_031839.3
NCBI Official Full Name
cytochrome P450 2C23
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily c, polypeptide 23
NCBI Official Symbol
Cyp2c23
NCBI Official Synonym Symbols
Cyp2c23
UniProt Protein Name
Cytochrome P450 2C23
UniProt Synonym Protein Names
Arachidonic acid epoxygenase; CYPIIC23
Protein Family
Cytochrome
UniProt Gene Name
Cyp2c23
UniProt Synonym Gene Names
Cyp2c-23
UniProt Entry Name
CP2CN_RAT
NCBI Protein Information
cytochrome P450 2C23; CYPIIC23; arachidonic acid epoxygenase

NCBI Summary for Cyp2c23

catalyzes the NADPH-dependent conversion of arachidonic acid to a mixture of epoxyeicosatrienic acids in arachidonic acid metabolism [RGD]

UniProt Comments for Cyp2c23

CYP2C44: Predominant enzyme isoform responsible for arachidonic acid epoxidation in the rat kidney. Catalyzes the NADPH-dependent metabolism of arachidonic acid to a mixture of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETS) as the only oxygenation products. Low rate of lauric acid hydroxylation at the (omega-1)-position

Protein type: Oxidoreductase

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity

Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process; epoxygenase P450 pathway; response to testosterone stimulus
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Research Articles on Cyp2c23

1. High dietary potassium enhances the inhibitory effect of arachidonic acid and 11,12-epoxyeicosatrienoic acid on ENaC by increasing cytochrome P450 epoxygenase activity and decreasing soluble epoxide hydrolase activity, respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cyp2c23 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram

Organs/Tissues associated with anti-Cyp2c23 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >33 publications with Cyp2c23 and Kidney
 Liver Antibodies  >8 publications with Cyp2c23 and Liver
 Testis Antibodies  >2 publications with Cyp2c23 and Testis
 Lung Antibodies  >2 publications with Cyp2c23 and Lung
 Brain Antibodies  >1 publications with Cyp2c23 and Brain
 Spleen Antibodies  >1 publications with Cyp2c23 and Spleen
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